Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation of large numbers of multiple mature cell types, starting from a relatively small stem cell compartment. A highly complex but efficient regulatory network is necessary to tightly control this production and to...

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Bibliographic Details
Published in:Blood 2000-09, Vol.96 (6), p.2022-2036
Main Authors: Fortunel, Nicolas O., Hatzfeld, Antoinette, Hatzfeld, Jacques A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Fundamental and applied biological sciences. Psychology
Hematopoiesis
Humans
Molecular and cellular biology
Signal Transduction - physiology
Transforming Growth Factor beta - physiology
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Summary:Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation of large numbers of multiple mature cell types, starting from a relatively small stem cell compartment. A highly complex but efficient regulatory network is necessary to tightly control this production and to maintain the hematopoietic tissue in homeostasis. During the last 3 decades, constantly growing numbers of molecules involved in this regulation have been identified. They include soluble cytokines and growth factors, cell–cell interaction molecules, and extracellular matrix components, which provide a multifunctional scaffolding specific for each tissue. The cloning of numerous growth factors and their mass production have led to their possible use for both fundamental research and clinical application.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V96.6.2022