In Vitro Analyses of Diamond-like Carbon Coated Stents: Reduction of Metal Ion Release, Platelet Activation, and Thrombogenicity

Coronary artery stents can induce platelet activation by shear forces, contact to the biomaterial, and release of metal ions. This activation is one important trigger for thrombosis. Coating of stents is a possible approach to prevent this side effect. The purpose of this study was to evaluate in vi...

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Bibliographic Details
Published in:Thrombosis research 2000-09, Vol.99 (6), p.577-585
Main Authors: Gutensohn, K., Beythien, C., Bau, J., Fenner, T., Grewe, P., Koester, R., Padmanaban, K., Kuehnl, P.
Format: Article
Language:English
Subjects:
Alloys
Biocompatability
Biological and medical sciences
Blood Platelets - chemistry
Carbon
Chromium - analysis
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - standards
DLC
Electron Probe Microanalysis
Flow Cytometry
Humans
Intracoronary stents
Ions - analysis
Mass Spectrometry
Medical sciences
Metals, Heavy - analysis
Nickel - analysis
Platelet Activation
Prosthesis Design
Spectrophotometry, Atomic
Stents - adverse effects
Stents - standards
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Thrombosis - etiology
Thrombosis - prevention & control
Time Factors
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Summary:Coronary artery stents can induce platelet activation by shear forces, contact to the biomaterial, and release of metal ions. This activation is one important trigger for thrombosis. Coating of stents is a possible approach to prevent this side effect. The purpose of this study was to evaluate in vitro the biocompatibility of stents coated with diamond-like carbon (DLC). Semiquantitative energy-dispersive X-ray microanalyses showed a complete coverage of the DLC stents. Flow cytometric analyses revealed a significantly higher increase of mean channel fluorescence intensity for the activation-dependent antigens CD62p and CD63 in non-coated compared to DLC-coated stents ( p
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(00)00295-4