Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila

Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long unbranched chains of repeating disaccharides. Numerous biochemical studies of these extracellular matrix molecules have implicated them in a variety of biological phenomena, in...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2000-10, Vol.12 (5), p.575-580
Main Authors: Baeg, Gyeong-Hun, Perrimon, Norbert
Format: Article
Language:English
Subjects:
Animals
cell-cell interactions
Coreceptor
Drosophila
Drosophila - metabolism
Drosophila - physiology
Drosophila Proteins
Fibroblast Growth Factors - metabolism
Hedgehog protein
Hedgehog Proteins
heparan sulfate
Heparan Sulfate Proteoglycans - metabolism
Hh movement
HS biosynthesis
HSPG
Insect Proteins - metabolism
Protein Binding
proteoglycans
Proto-Oncogene Proteins - physiology
Segment polarity phenotype
Signal Transduction
Wnt protein
Wnt1 Protein
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Summary:Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long unbranched chains of repeating disaccharides. Numerous biochemical studies of these extracellular matrix molecules have implicated them in a variety of biological phenomena, in particular cell–cell interactions. Recent genetic studies in Drosophila have begun to clarify the function of HSPGs in vivo and recent findings have implicated HSPGs in Wnt, Hedgehog, fibroblast growth factor and transforming growth factor-β signaling pathways during development.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00134-4