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Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila
Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long unbranched chains of repeating disaccharides. Numerous biochemical studies of these extracellular matrix molecules have implicated them in a variety of biological phenomena, in...
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| Published in: | Current Opinion in Cell Biology 2000-10, Vol.12 (5), p.575-580 |
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| Main Authors: | , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c458t-f8de51c02febcca0180440f28031caff91b0e4ac50a113bef48ffd692b8d7e323 |
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| cites | cdi_FETCH-LOGICAL-c458t-f8de51c02febcca0180440f28031caff91b0e4ac50a113bef48ffd692b8d7e323 |
| container_end_page | 580 |
| container_issue | 5 |
| container_start_page | 575 |
| container_title | Current Opinion in Cell Biology |
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| creator | Baeg, Gyeong-Hun Perrimon, Norbert |
| description | Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long unbranched chains of repeating disaccharides. Numerous biochemical studies of these extracellular matrix molecules have implicated them in a variety of biological phenomena, in particular cell–cell interactions. Recent genetic studies in
Drosophila have begun to clarify the function of HSPGs
in vivo and recent findings have implicated HSPGs in Wnt, Hedgehog, fibroblast growth factor and transforming growth factor-β signaling pathways during development. |
| doi_str_mv | 10.1016/S0955-0674(00)00134-4 |
| format | article |
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Drosophila have begun to clarify the function of HSPGs
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Drosophila have begun to clarify the function of HSPGs
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| identifier | ISSN: 0955-0674 |
| ispartof | Current Opinion in Cell Biology, 2000-10, Vol.12 (5), p.575-580 |
| issn | 0955-0674 1879-0410 |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals cell-cell interactions Coreceptor Drosophila Drosophila - metabolism Drosophila - physiology Drosophila Proteins Fibroblast Growth Factors - metabolism Hedgehog protein Hedgehog Proteins heparan sulfate Heparan Sulfate Proteoglycans - metabolism Hh movement HS biosynthesis HSPG Insect Proteins - metabolism Protein Binding proteoglycans Proto-Oncogene Proteins - physiology Segment polarity phenotype Signal Transduction Wnt protein Wnt1 Protein |
| title | Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila |
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