Aspiration cytodiagnosis of small cell malignancies found in fine needle aspirate (FNA) of the liver: an immunocytochemical study

Aspiration cytodiagnosis of small cell malignancies found in fine needle aspirate (FNA) of the liver: an immunocytochemical study In this study the features of small cell malignancies found in the liver by fine needle aspiration cytology (FNAC) and immunostains required for a diagnosis and different...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2000-08, Vol.11 (4), p.262-267
Main Authors: Gupta, R. K., Kenwright, D. N., Naran, S., Lallu, S., Fauck, R.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers
Biopsy, Needle
Cytodiagnosis - methods
Diagnosis, Differential
fine needle aspiration cytology
Humans
Immunoenzyme Techniques
immunostaining
liver
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Middle Aged
small cell malignancies
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Summary:Aspiration cytodiagnosis of small cell malignancies found in fine needle aspirate (FNA) of the liver: an immunocytochemical study In this study the features of small cell malignancies found in the liver by fine needle aspiration cytology (FNAC) and immunostains required for a diagnosis and differential diagnosis are presented. The material consisted of 197 fine needle aspirates which were performed under image guidance between January 1982 to October 1999. Of these, 30 were diagnosed as small cell malignancies. The age of patients ranged between 46 and 68 years. The aspirated material was examined using Papanicolaou‐stained filter preparations and cell blocks, the latter stained with hematoxylin and eosin and a panel of immunoperoxidase stains. The diagnoses based on a correlation of relevant clinical history, cytohistological findings and immunostaining were: metastatic small cell anaplastic carcinoma of lung (n = 6); neuroendocrine tumour (n = 9); non‐Hodgkin's lymphoma (n = 4); well‐differentiated cholangiocarcinoma (n = 2); metastatic carcinoma of the prostate (n = 2); metastatic adenocarcinoma (n = 4) and metastatic carcinoma breast (n = 3). This study emphasizes the wide range of neoplasms that enter into the differential diagnosis of small cell malignancies found in the liver and a correlation of clinical, cytohistological and immunostaining findings which seem to be useful in suggesting a diagnosis.
ISSN:0956-5507
1365-2303
DOI:10.1046/j.1365-2303.2000.00258.x