Effect of intratesticular administration of TRH or anti-TRH antiserum on function of rat testis

The effect of intratesticular administration of thyrotropin-releasing hormone (TRH) and anti-TRH antiserum on steroidogenesis was studied in immature and adult rats. In 9-day-old animals local administration of the neuropeptide resulted in an increase in basal testosterone secretion in vitro. Simila...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2000-06, Vol.67 (3), p.269-281
Main Authors: Gerendai, Ida, Sziebert, Péter, Görcs, Tamás, Csaba, Zsolt, Csernus, Valér
Format: Article
Language:English
Subjects:
Age-dependent effect
Aging - physiology
Animals
Anti-TRH antiserum
Chorionic Gonadotropin - pharmacology
Drug Administration Routes
Female
Immune Sera - immunology
Immune Sera - pharmacology
Local control
Male
Neuropeptide
Orchiectomy
Pregnancy
Rats
Steroidogenesis
Stimulation, Chemical
Testis - drug effects
Testis - metabolism
Testis - physiology
Testosterone - biosynthesis
Testosterone - blood
Testosterone - metabolism
Thyrotropin-Releasing Hormone - immunology
Thyrotropin-Releasing Hormone - pharmacology
TRH
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of intratesticular administration of thyrotropin-releasing hormone (TRH) and anti-TRH antiserum on steroidogenesis was studied in immature and adult rats. In 9-day-old animals local administration of the neuropeptide resulted in an increase in basal testosterone secretion in vitro. Similar treatment of 15-day-old rats suppressed hCG-stimulated testosterone secretion with no change in basal testosterone production. In both immature groups the treatment did not affect serum testosterone concentration. By contrast, in adults TRH decreased serum testosterone level, but did not influence basal and hCG-stimulated testosterone secretion. Both in immature and adult rats, the changes in steroidogenesis were evident 1 hour posttreatment. Five days after the administration of anti-TRH antiserum into the remaining testis of immature rats subjected to hemicastration just prior to the antiserum treatment, the alterations in steroidogenesis were opposite to those detected after treatment with TRH. In 9-day-old rats the antiserum suppressed steroidogenesis, while in 15-day-old animals it stimulated testosterone secretion. The results suggest that testicular TRH might exert a local action on testicular steroidogenesis, and the effect is age-dependent.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(00)00623-8