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Rizatriptan for acute migraine
There are a number of different drug treatments for acute migraine, including currently four triptans, with several more likely to become available in the future. There is a need for evidence-based information to help determine the balance of benefit and harm for acute migraine treatment. To quantit...
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Published in: | Cochrane database of systematic reviews 2001 (3), p.CD003221-CD003221 |
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creator | Oldman, A D Smith, L A McQuay, H J Moore, R A |
description | There are a number of different drug treatments for acute migraine, including currently four triptans, with several more likely to become available in the future. There is a need for evidence-based information to help determine the balance of benefit and harm for acute migraine treatment.
To quantitatively assess the efficacy of a single dose of rizatriptan (Maxalt) for treating a single migraine attack using the outcomes of headache response and pain-free response at half-an-hour, one hour, two hours, and sustained relief over 24 hours. To express efficacy in terms of numbers-needed-to-treat (NNTs).
Trials were identified by searching MEDLINE (1966-July 2000), EMBASE (1980-June 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (1950-1994). Date of last search: July 2000.
The inclusion criteria were randomised, placebo-controlled trials of rizatriptan for acute migraine; double-blind design; International Headache Society diagnostic criteria for migraine with or without aura; single migraine attack; single-dose treatment at standard doses; adult population; baseline pain of moderate or severe intensity using a four-point standardised rating scale; dichotomous or percentage data for at least one of the main efficacy outcomes; and full journal publication.
Main outcomes considered were i) headache response at two hours, ii) headache response at one hour, iii) pain-free response at two hours, iv) sustained relief over 24 hours, v) pain-free response at 24 hours and vi) adverse effects. Minor outcomes were headache response and pain-free response at half-an-hour and four hours, and pain-free response at one hour. Dichotomous or percentage data were extracted and used to calculate the relative benefit (RB) and number-needed-to-treat (NNT) for each outcome.
Seven trials met our inclusion criteria, with 2626 patients given rizatriptan and 902 given placebo. Significant benefit of rizatriptan over placebo was shown for both doses of rizatriptan (5 mg and 10 mg) for all five main efficacy outcomes (ranging from one to 24 hours). A dose response was seen for the main outcomes. It was not possible to analyse adverse effects information in a meaningful way.
Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy. |
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To quantitatively assess the efficacy of a single dose of rizatriptan (Maxalt) for treating a single migraine attack using the outcomes of headache response and pain-free response at half-an-hour, one hour, two hours, and sustained relief over 24 hours. To express efficacy in terms of numbers-needed-to-treat (NNTs).
Trials were identified by searching MEDLINE (1966-July 2000), EMBASE (1980-June 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (1950-1994). Date of last search: July 2000.
The inclusion criteria were randomised, placebo-controlled trials of rizatriptan for acute migraine; double-blind design; International Headache Society diagnostic criteria for migraine with or without aura; single migraine attack; single-dose treatment at standard doses; adult population; baseline pain of moderate or severe intensity using a four-point standardised rating scale; dichotomous or percentage data for at least one of the main efficacy outcomes; and full journal publication.
Main outcomes considered were i) headache response at two hours, ii) headache response at one hour, iii) pain-free response at two hours, iv) sustained relief over 24 hours, v) pain-free response at 24 hours and vi) adverse effects. Minor outcomes were headache response and pain-free response at half-an-hour and four hours, and pain-free response at one hour. Dichotomous or percentage data were extracted and used to calculate the relative benefit (RB) and number-needed-to-treat (NNT) for each outcome.
Seven trials met our inclusion criteria, with 2626 patients given rizatriptan and 902 given placebo. Significant benefit of rizatriptan over placebo was shown for both doses of rizatriptan (5 mg and 10 mg) for all five main efficacy outcomes (ranging from one to 24 hours). A dose response was seen for the main outcomes. It was not possible to analyse adverse effects information in a meaningful way.
Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy.</description><identifier>EISSN: 1469-493X</identifier><identifier>PMID: 11687054</identifier><language>eng</language><publisher>England</publisher><subject>Acute Disease ; Humans ; Migraine Disorders - drug therapy ; Randomized Controlled Trials as Topic ; Serotonin Receptor Agonists - therapeutic use ; Triazoles - therapeutic use ; Tryptamines</subject><ispartof>Cochrane database of systematic reviews, 2001 (3), p.CD003221-CD003221</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11687054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oldman, A D</creatorcontrib><creatorcontrib>Smith, L A</creatorcontrib><creatorcontrib>McQuay, H J</creatorcontrib><creatorcontrib>Moore, R A</creatorcontrib><title>Rizatriptan for acute migraine</title><title>Cochrane database of systematic reviews</title><addtitle>Cochrane Database Syst Rev</addtitle><description>There are a number of different drug treatments for acute migraine, including currently four triptans, with several more likely to become available in the future. There is a need for evidence-based information to help determine the balance of benefit and harm for acute migraine treatment.
To quantitatively assess the efficacy of a single dose of rizatriptan (Maxalt) for treating a single migraine attack using the outcomes of headache response and pain-free response at half-an-hour, one hour, two hours, and sustained relief over 24 hours. To express efficacy in terms of numbers-needed-to-treat (NNTs).
Trials were identified by searching MEDLINE (1966-July 2000), EMBASE (1980-June 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (1950-1994). Date of last search: July 2000.
The inclusion criteria were randomised, placebo-controlled trials of rizatriptan for acute migraine; double-blind design; International Headache Society diagnostic criteria for migraine with or without aura; single migraine attack; single-dose treatment at standard doses; adult population; baseline pain of moderate or severe intensity using a four-point standardised rating scale; dichotomous or percentage data for at least one of the main efficacy outcomes; and full journal publication.
Main outcomes considered were i) headache response at two hours, ii) headache response at one hour, iii) pain-free response at two hours, iv) sustained relief over 24 hours, v) pain-free response at 24 hours and vi) adverse effects. Minor outcomes were headache response and pain-free response at half-an-hour and four hours, and pain-free response at one hour. Dichotomous or percentage data were extracted and used to calculate the relative benefit (RB) and number-needed-to-treat (NNT) for each outcome.
Seven trials met our inclusion criteria, with 2626 patients given rizatriptan and 902 given placebo. Significant benefit of rizatriptan over placebo was shown for both doses of rizatriptan (5 mg and 10 mg) for all five main efficacy outcomes (ranging from one to 24 hours). A dose response was seen for the main outcomes. It was not possible to analyse adverse effects information in a meaningful way.
Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy.</description><subject>Acute Disease</subject><subject>Humans</subject><subject>Migraine Disorders - drug therapy</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Serotonin Receptor Agonists - therapeutic use</subject><subject>Triazoles - therapeutic use</subject><subject>Tryptamines</subject><issn>1469-493X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNo1j8tKAzEUQIMgtrb-QpmVu4G5eUySpRRfUBBEobvhTnIjkXmZzCz06xVsV2dzOHAu2BpkbUtpxXHFrnP-rCphAcwVWwHURldKrtnuNf7gnOI041CEMRXolpmKPn4kjANt2WXALtPNiRv2_nD_tn8qDy-Pz_u7QzkB53MZUNfKk9YoeLC2CiEoEYxqwZMySKi8MtZxMN65NkhZg1cVkVWonfJBbNjtf3dK49dCeW76mB11HQ40LrnRnEsDAv7E3Ulc2p58M6XYY_puzkfiF0CYRlM</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Oldman, A D</creator><creator>Smith, L A</creator><creator>McQuay, H J</creator><creator>Moore, R A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Rizatriptan for acute migraine</title><author>Oldman, A D ; Smith, L A ; McQuay, H J ; Moore, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-fa765de77a32f990fff53f85b1de58aea5d589c218dccbf4461d50ee95a7c5df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Disease</topic><topic>Humans</topic><topic>Migraine Disorders - drug therapy</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Serotonin Receptor Agonists - therapeutic use</topic><topic>Triazoles - therapeutic use</topic><topic>Tryptamines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oldman, A D</creatorcontrib><creatorcontrib>Smith, L A</creatorcontrib><creatorcontrib>McQuay, H J</creatorcontrib><creatorcontrib>Moore, R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cochrane database of systematic reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oldman, A D</au><au>Smith, L A</au><au>McQuay, H J</au><au>Moore, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rizatriptan for acute migraine</atitle><jtitle>Cochrane database of systematic reviews</jtitle><addtitle>Cochrane Database Syst Rev</addtitle><date>2001</date><risdate>2001</risdate><issue>3</issue><spage>CD003221</spage><epage>CD003221</epage><pages>CD003221-CD003221</pages><eissn>1469-493X</eissn><abstract>There are a number of different drug treatments for acute migraine, including currently four triptans, with several more likely to become available in the future. There is a need for evidence-based information to help determine the balance of benefit and harm for acute migraine treatment.
To quantitatively assess the efficacy of a single dose of rizatriptan (Maxalt) for treating a single migraine attack using the outcomes of headache response and pain-free response at half-an-hour, one hour, two hours, and sustained relief over 24 hours. To express efficacy in terms of numbers-needed-to-treat (NNTs).
Trials were identified by searching MEDLINE (1966-July 2000), EMBASE (1980-June 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (1950-1994). Date of last search: July 2000.
The inclusion criteria were randomised, placebo-controlled trials of rizatriptan for acute migraine; double-blind design; International Headache Society diagnostic criteria for migraine with or without aura; single migraine attack; single-dose treatment at standard doses; adult population; baseline pain of moderate or severe intensity using a four-point standardised rating scale; dichotomous or percentage data for at least one of the main efficacy outcomes; and full journal publication.
Main outcomes considered were i) headache response at two hours, ii) headache response at one hour, iii) pain-free response at two hours, iv) sustained relief over 24 hours, v) pain-free response at 24 hours and vi) adverse effects. Minor outcomes were headache response and pain-free response at half-an-hour and four hours, and pain-free response at one hour. Dichotomous or percentage data were extracted and used to calculate the relative benefit (RB) and number-needed-to-treat (NNT) for each outcome.
Seven trials met our inclusion criteria, with 2626 patients given rizatriptan and 902 given placebo. Significant benefit of rizatriptan over placebo was shown for both doses of rizatriptan (5 mg and 10 mg) for all five main efficacy outcomes (ranging from one to 24 hours). A dose response was seen for the main outcomes. It was not possible to analyse adverse effects information in a meaningful way.
Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy.</abstract><cop>England</cop><pmid>11687054</pmid></addata></record> |
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identifier | EISSN: 1469-493X |
ispartof | Cochrane database of systematic reviews, 2001 (3), p.CD003221-CD003221 |
issn | 1469-493X |
language | eng |
recordid | cdi_proquest_miscellaneous_72248131 |
source | Alma/SFX Local Collection |
subjects | Acute Disease Humans Migraine Disorders - drug therapy Randomized Controlled Trials as Topic Serotonin Receptor Agonists - therapeutic use Triazoles - therapeutic use Tryptamines |
title | Rizatriptan for acute migraine |
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