Cross-talk in kidney development

As in most organs, the emerging theme in kidney development is the importance of cross-talk between several tissues and cell lineages to allow morphogenesis to proceed in a complex but highly regulated way. Over the past few years, knock-out and transgenic analyses in mice and evolutionary compariso...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Genetics & Development 2000-10, Vol.10 (5), p.543-549
Main Authors: Schedl, Andreas, Hastie, Nicholas D
Format: Article
Language:English
Subjects:
Animals
Bmp
c-Ret
c-Ret protein
DNA-Binding Proteins - physiology
Emx2
Eya1
eya1 protein
Gdnf
Gdnf protein
GdnfR^a protein
Glial Cell Line-Derived Neurotrophic Factor
Growth Inhibitors - physiology
Humans
Interleukin-6
Kidney - embryology
Kidney induction
Leukemia Inhibitory Factor
LIF protein
Lymphokines - physiology
Metanephros
Nerve Growth Factors
Nerve Tissue Proteins - physiology
Pax2
Pax2 protein
PAX2 Transcription Factor
Signal Transduction - physiology
Transcription Factors - physiology
Ureteric bud
wnt protein
wt1 protein
WT1 Proteins
Wtl
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As in most organs, the emerging theme in kidney development is the importance of cross-talk between several tissues and cell lineages to allow morphogenesis to proceed in a complex but highly regulated way. Over the past few years, knock-out and transgenic analyses in mice and evolutionary comparison with non-mammalian species have been particularly instrumental in identifying molecules with crucial functions for tissue–tissue interactions. The transcription factors Wt1 and Eya1, the signalling molecules Gdnf and LIF and the receptors c-Ret and GdnfRα have been demonstrated to fulfil fundamental roles in the first step of metanephric induction, the outgrowth of the ureter. Signalling by members of the Wnt, BMP and FGF families, regulated by transcription factors such as Pax2, mediates nephrogenesis by adjusting the balance between the ureteric bud epithelium, stromal and nephrogenic tissues. The stromal tissue, neglected for many years, has been shown to serve important functions in regulating the growth of nephrons. Finally, we have also begun to gain insight into the molecular events underlying patterning of the nephron into distinct functional units including glomerulus, proximal and distal tubule.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00125-8