Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

In patch-clamp recordings from small–medium diameter dorsal root ganglion neurons in culture, (±)-epibatidine (1 μM) was able to inhibit the capsaicin response (IC 50=0.32 μM) in neurons where there was no detectable direct nicotinic response. Thus, (±)-epibatidine may inhibit the vanilloid receptor...

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Bibliographic Details
Published in:Brain research 2001-11, Vol.919 (1), p.166-168
Main Authors: Zhang, Xu-Feng, McKenna, David G., Briggs, Clark A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Bridged Bicyclo Compounds, Heterocyclic - pharmacology
Capsaicin
Capsaicin - antagonists & inhibitors
Capsaicin - pharmacology
Cells, Cultured
Central nervous system
Dorsal root ganglion
Dose-Response Relationship, Drug
Electrophysiology
Epibatidine
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - drug effects
Ganglia, Spinal - physiology
Neurons - drug effects
Neurons - physiology
Nicotinic acetylcholine receptor
Nicotinic Agonists - pharmacology
Pain
Pyridines - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic - physiology
Vanilloid receptor
vanilloid receptors
Vertebrates: nervous system and sense organs
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Summary:In patch-clamp recordings from small–medium diameter dorsal root ganglion neurons in culture, (±)-epibatidine (1 μM) was able to inhibit the capsaicin response (IC 50=0.32 μM) in neurons where there was no detectable direct nicotinic response. Thus, (±)-epibatidine may inhibit the vanilloid receptor in a manner that is not dependent upon nicotinic current activation, representing another mechanism by which such ligands could modulate vanilloid receptor signaling.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)03028-1