A New Route to Spirooxindoles

Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.

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Bibliographic Details
Published in:Organic letters 2000-08, Vol.2 (17), p.2639-2641
Main Authors: Hilton, Stephen T, Ho, Tim C. T, Pljevaljcic, Goran, Jones, Keith
Format: Article
Language:English
Subjects:
Cyclization
Indicators and Reagents
Indoles - chemistry
Magnetic Resonance Spectroscopy
Methacrylates
Spiro Compounds - chemical synthesis
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Description
Summary:Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0061642