Hyperfluorescence associated with serous retinal pigment epithelial detachment on indocyanine green angiography

• Published in: Acta ophthalmologica Scandinavica 2000-08, Vol.78 (4), p.443-447
• Main Authors: Parodi, Maurizio Battaglia, Saviano, Sandro, Bondel, Elvio, Panetta, Paolo, Iustulin, Daniele, Fachin, Sandro, Ravalico, Giuseppe
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Choroidal Neovascularization - diagnosis; Choroidal Neovascularization - etiology; Choroidal Neovascularization - surgery; Fluorescein Angiography; Fluorescence; Humans; hyperfluorescence; Indocyanine Green; indocyanine green angiography; Laser Coagulation; Macular Degeneration - complications; Macular Degeneration - diagnosis; Macular Degeneration - surgery; Middle Aged; Pigment Epithelium of Eye - pathology; Prospective Studies; Retinal Detachment - diagnosis; Retinal Detachment - etiology; Retinal Detachment - surgery; serous retinal pigment epithelial detachment; Visual Acuity
• ISSN: 1395-3907; 1600-0420
• DOI: 10.1034/j.1600-0420.2000.078004443.x

Purpose: Indocyanine green angiography has been reported to improve detection and delineation of occult choroidal neovascularisation in serous pigment epithelium detachment in age‐related macular degeneration. The study aims to evaluate the visual acuity results of eyes affected by serous pigment epithelium detachment in age‐related macular degeneration, having had indocyanine green‐directed laser photocoagulation, and to correlate them to the pattern of serous pigment epithelium detachment on indocyanine green angiography. Methods: Thirty‐four eyes of 31 patients affected by serous pigment epithelium detachment in age‐related macular degeneration were prospectively considered. Each patient underwent an ophthalmological examination including fluorescein and indocyanine green angiography one day before, and 6 weeks, 3 months, 6 months, 9 months, 12 months and 24 months after krypton‐laser treatment. The serous pigment epithelium detachment was classified in the late‐phases angiograms as either hypofluorescent, isofluorescent or hyperfluorescent comparing the fluorescence of the serous pigment epithelium detachment with the choroidal background fluorescence. Results: The indocyanine green‐guided laser treatment was associated with a temporary stabilization and a long‐term progressive reduction of visual acuity: after 24 months visual acuity improved in 2.9%, stabilized in 26.5% and worsened in 70.5% of cases. Serous pigment epithelium detachment presenting a pretreatment hyperfluorescence had a final visual acuity of 0.06, with subfoveal choroidal neovascularisation development in 100% of cases, whereas serous pigment epithelium detachment presenting a pretreatment hypofluorescence and isofluorescence showed a final visual acuity of 0.12, with subfoveal choroidal neovascularisation development in 43.5% of eyes, with statistically significant difference. Conclusion: Overall visual acuity decreases with time after indocyanine green‐guided laser treatment of choroidal neovascularisation in serous pigment epithelium detachment, and serous pigment epithelium detachment becoming hyperfluorescent in the late‐phases of indocyanine green angiography has the worst functional outcome.