Chromosome cohesion and segregation in mitosis and meiosis

The faithful segregation of the genetic material into daughter cells during cell division is crucial for the production of healthy progeny. Sister chromatid cohesion and separation are fundamental to this process. Progress has been made in our molecular understanding of cohesion and mechanisms for t...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2001-12, Vol.13 (6), p.754-761
Main Author: Uhlmann, Frank
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins
cell division
Chromatids - genetics
Chromosomal Proteins, Non-Histone
Chromosome Segregation
Chromosomes - genetics
Chromosomes - metabolism
cohesin
Cohesins
Fungal Proteins
Humans
Macromolecular Substances
Meiosis
Mitosis
Models, Genetic
Nuclear Proteins - physiology
separase
sister chromatid cohesion
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Summary:The faithful segregation of the genetic material into daughter cells during cell division is crucial for the production of healthy progeny. Sister chromatid cohesion and separation are fundamental to this process. Progress has been made in our molecular understanding of cohesion and mechanisms for the dissolution of cohesion have been uncovered. The successful segregation of genetic material into daughter cells during cell division is crucial. Sister chromatid cohesion and separation are fundamental to this process and Uhlmann discusses this in detail.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00279-9