Reactive nitrogen and oxygen species in airway inflammation

The free radical nitric oxide (NO) is an important mediator of many biological processes. Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function as a paracrine messenger, NO-derived oxidants are important weapons against invading pathogens. The role of NO in the...

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Bibliographic Details
Published in:European Journal of Pharmacology 2001-10, Vol.429 (1), p.251-262
Main Authors: Folkerts, Gert, Kloek, Joris, Muijsers, Richard B.R, Nijkamp, Frans P
Format: Article
Language:English
Subjects:
Airway
Animals
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Humans
Inflammation - metabolism
Lung
Lung - metabolism
Lung - pathology
Medical sciences
Nitric oxide (NO)
Peroxynitrite
Pneumology
Radical
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
Super oxide
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Summary:The free radical nitric oxide (NO) is an important mediator of many biological processes. Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function as a paracrine messenger, NO-derived oxidants are important weapons against invading pathogens. The role of NO in the airways is similarly ambiguous. Besides the task as a bronchodilator, NO and its derivatives play a role in the pathophysiology of asthma via their putative damaging effects on the airways. This deleterious effect can be increased by a nitrosative response to respiratory tract infections, since both the infectious agent and the host may suffer from the consequent nitrosative stress. Interestingly, respiratory infections can also compromise the beneficial (bronchodilator) effects of NO. This paper gives an overview on NO and its derivatives in the pathophysiology of airway inflammation.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(01)01324-3