Development of Intimal Hyperplasia in Six Different Vascular Prostheses

Objectives: to compare six vascular prostheses for the development of intimal hyperplasia (IH) in a sheep model. Material and methods: prostheses tested were gelatin sealed Dacron (GSD), fluoropassivated Dacron (FPD), FluroÍpassiv TM (FD), expanded polytetrafluoroethylene (ePTFE), carbon-lined expan...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2000-09, Vol.20 (3), p.241-249
Main Authors: Ao, PY, Hawthorne, WJ, Vicaretti, M, Fletcher, JP
Format: Article
Language:English
Subjects:
Animals
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Carbon
Carotid Artery, Common - pathology
Carotid Artery, Common - surgery
Female
Hyperplasia
Intimal hyperplasia
Polyester
Polyesters
Polyethylene Terephthalates
Polytetrafluoroethylene
Polyurethane
Polyurethanes
Sheep
Tunica Intima - pathology
Vascular prostheses
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Summary:Objectives: to compare six vascular prostheses for the development of intimal hyperplasia (IH) in a sheep model. Material and methods: prostheses tested were gelatin sealed Dacron (GSD), fluoropassivated Dacron (FPD), FluroÍpassiv TM (FD), expanded polytetrafluoroethylene (ePTFE), carbon-lined expanded polytetrafluoroethylene (CL-ePTFE) and vascular access graft (VAG). Sixty-two adult female Merino sheep (35–45 kg) were used. Elliptical graft patches were implanted into the left common carotid artery using one of the six graft types: GSD (n=10), FPD (n=10), FD (n=12) VAG (n=10), ePTFE (n=10), or CL-ePTFE (n=10). Four weeks later grafts were removed for histopathological assessment and measurement of the degree of IH obtained on a computerised image analysis system.Results: IH indices were significantly less for FPD (0.191±0.095, p
ISSN:1078-5884
1532-2165
DOI:10.1053/ejvs.2000.1177