Patterns of abnormal FDG uptake by various histological types of non-small cell lung cancer at initial staging by PET

The aim of this study was to identify useful patterns of abnormal fluorine-18 fluorodeoxyglucose (FDG) uptake by different types of non-small cell (NSC) lung cancer and to assess their clinical implications. One hundred and three sequential patients with newly diagnosed, pathology-proven NSC lung ca...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 2001-11, Vol.28 (11), p.1702-1705
Main Authors: WONG, Ching-Yee O, NUNEZ, Rodolfo, DICKINSON, Christine, DWORKIN, Howard J, BOHDIEWICZ, Paul, WELSH, Robert J, CHMIELEWSKI, Gary W, RAVIKRISHNAN, Korembeth P, HILL, Jack C, PURSEL, Stewart E, FINK-BENNETT, Darlene, BALON, Helena
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
Biological and medical sciences
Carcinoma, Large Cell - diagnostic imaging
Carcinoma, Large Cell - pathology
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - pathology
Fluorodeoxyglucose F18
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Medical sciences
Neoplasm Staging
Radionuclide investigations
Radiopharmaceuticals
Respiratory system
Tomography, Emission-Computed
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Summary:The aim of this study was to identify useful patterns of abnormal fluorine-18 fluorodeoxyglucose (FDG) uptake by different types of non-small cell (NSC) lung cancer and to assess their clinical implications. One hundred and three sequential patients with newly diagnosed, pathology-proven NSC lung cancer were included. FDG positron emission tomography (PET) images were acquired using a dedicated PET scanner. There were 35 squamous cell carcinomas (SQC), 17 large cell cancers (LGC), 38 adenocarcinomas (ADC), 1 bronchioloalveolar carcinoma (BAC) and 12 non-classified NSC cancers. PET images were categorized into detectable patterns of necrotic center in the primary tumor, satellite lesions (T4), hilar lymph nodes (N1), and N2, N3, and M1 lesions by visual interpretation of PET images for SQC, LGC, and ADC (n=90; BAC and non-classified NSC cancers were excluded). The PET lesions were correlated with surgical pathology and with CT findings in inoperable cases. Necrosis was more commonly present in the primary tumors of LGC (53%) and SQC (43%) than in those of ADC (26%) (P
ISSN:0340-6997
1619-7089
DOI:10.1007/s002590100638