Diagnostic accuracy of low-dose dobutamine echocardiography in predicting post-revascularisation recovery of function in patients with chronic coronary artery disease : relationship to thallium-201 uptake

It is known that contractile reserve may be blunted if perfusion and coronary flow reserve are reduced. Thus, it is conceivable that the predictive accuracy of dobutamine echocardiography may differ according to perfusion tracer uptake. The aim of this study was therefore to assess the relationship...

Full description

Saved in:
Bibliographic Details
Published in:European Journal of Nuclear Medicine 2001-11, Vol.28 (11), p.1616-1623
Main Authors: PACE, Leonardo, PERRONE FILARDI, Pasquale, SALVATORE, Marco, CUOCOLO, Alberto, PRASTARO, Mariella, ACAMPA, Wanda, DELLEGROTTAGLIE, Santo, STORTO, Giovanni, DELLA MORTE, Anna Maria, PISCIONE, Federico, CHIARIELLO, Massimo
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiovascular system
Coronary Disease - diagnostic imaging
Coronary Disease - physiopathology
Coronary Disease - therapy
Dobutamine
Echocardiography, Stress
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Contraction
Myocardial Revascularization
Predictive Value of Tests
Recovery of Function
Sensitivity and Specificity
Thallium Radioisotopes
Tomography, Emission-Computed, Single-Photon
Ultrasonic investigative techniques
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is known that contractile reserve may be blunted if perfusion and coronary flow reserve are reduced. Thus, it is conceivable that the predictive accuracy of dobutamine echocardiography may differ according to perfusion tracer uptake. The aim of this study was therefore to assess the relationship between the level of thallium-201 uptake and the accuracy of dobutamine echocardiography in identifying reversible dysfunction. Sixty-nine patients (age 59+/-8 years, ejection fraction 40%+/-11%) with chronic coronary artery disease scheduled for coronary revascularisation were studied. All patients underwent rest 201Tl single-photon emission tomography and two-dimensional echocardiography at rest and during low-dose dobutamine infusion on the same day before revascularisation and repeated echocardiography at least 30 days thereafter. At follow-up, recovery of function was observed in 49% of 339 dysfunctional segments. The percentage of segments with post-revascularisation recovery of function and the percentage with contractile reserve increased in parallel with 201Tl uptake both in the total group of segments (chi2=35.5, P
ISSN:0340-6997
1619-7070
1619-7089
DOI:10.1007/s002590100608