Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus

In order to characterize the ontogenetic profile of metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu receptor agonist 3,5-dihydroxyphenylglycine stimulated...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2001-10, Vol.26 (10), p.1151-1155
Main Authors: ATTUCCI, Sabina, ALBANI-TORREGROSSA, Serenella, MORONI, Flavio, PELLEGRINI-GIAMPIETRO, Domenico E
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Animals, Newborn
Biological and medical sciences
Cycloleucine - analogs & derivatives
Cycloleucine - pharmacology
Cyclopropanes - pharmacology
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Glycine - analogs & derivatives
Glycine - pharmacology
Hippocampus - growth & development
Hippocampus - physiology
Kinetics
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - pharmacology
Phospholipase D - metabolism
Rats
Rats, Wistar
Receptors, Metabotropic Glutamate - agonists
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, Metabotropic Glutamate - physiology
Vertebrates: nervous system and sense organs
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In order to characterize the ontogenetic profile of metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu receptor agonist 3,5-dihydroxyphenylglycine stimulated PLD in immature tissue, but reduced the PLD response evoked by the nonselective mGlu receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate [(1S,3R)-ACPD] in adult hippocampus. (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl) glycine (PCCG-13), a recently characterized selective antagonist of PLD-coupled mGlu receptors, displayed a much greater activity in reducing the PLD response to (1S,3R)-ACPD in adult than in neonate hippocampus. Our results lend support to the hypothesis that glutamatergic activation of PLD in the rat hippocampus is developmentally regulated.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1012327007733