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Linkage of body mass index to chromosome 20 in Utah pedigrees
Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigree...
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| Published in: | Human genetics 2001-09, Vol.109 (3), p.279-285 |
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| container_end_page | 285 |
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| container_title | Human genetics |
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| creator | HUNT, Steven C ABKEVICH, Victor WEAVER-FELDHAUS, Jane MACALMA, Tess RICHARDS, Maria M GRESS, Richard FRANCIS, Mike THOMAS, Alun FRECH, Georges C ADAMS, Ted D SHATTUCK, Donna STONE, Steven HENSEL, Charles H GUTIN, Alexander NEFF, Chris D RUSSELL, Deanna L TRAN, Thanh XIANKANG HONG JAMMULAPATI, Srikanth RILEY, Robyn |
| description | Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a maximum multipoint heterogeneity LOD score of 3.5 at D20S438 (55.1 cM). Two additional analyses were performed. First, a one-gene, two-mutation model (with one dominant mutation and one recessive mutation) increased the LOD score to 4.2. Second, a two-locus model (with one locus dominant and one recessive) generated a multipoint LOD score of 4.9. We conclude that one or more severe obesity predisposing genes lie within an interval of approx. 10 cM on chromosome 20. This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere. |
| doi_str_mv | 10.1007/s004390100581 |
| format | article |
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Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a maximum multipoint heterogeneity LOD score of 3.5 at D20S438 (55.1 cM). Two additional analyses were performed. First, a one-gene, two-mutation model (with one dominant mutation and one recessive mutation) increased the LOD score to 4.2. Second, a two-locus model (with one locus dominant and one recessive) generated a multipoint LOD score of 4.9. We conclude that one or more severe obesity predisposing genes lie within an interval of approx. 10 cM on chromosome 20. This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s004390100581</identifier><identifier>PMID: 11702208</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Body Mass Index ; Centromere - genetics ; Chromosomes, Human, Pair 20 - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, Dominant ; Genes, Recessive ; Genetic Linkage ; Genetic Markers ; Genotype ; Humans ; Lod Score ; Male ; Models, Genetic ; Molecular and cellular biology ; Obesity - genetics ; Pedigree ; Phenotype ; Utah</subject><ispartof>Human genetics, 2001-09, Vol.109 (3), p.279-285</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-e8076150a3ea3764b730a4adecd99c20a813b2c356bfa34789f110a30096de0c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14159402$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11702208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUNT, Steven C</creatorcontrib><creatorcontrib>ABKEVICH, Victor</creatorcontrib><creatorcontrib>WEAVER-FELDHAUS, Jane</creatorcontrib><creatorcontrib>MACALMA, Tess</creatorcontrib><creatorcontrib>RICHARDS, Maria M</creatorcontrib><creatorcontrib>GRESS, Richard</creatorcontrib><creatorcontrib>FRANCIS, Mike</creatorcontrib><creatorcontrib>THOMAS, Alun</creatorcontrib><creatorcontrib>FRECH, Georges C</creatorcontrib><creatorcontrib>ADAMS, Ted D</creatorcontrib><creatorcontrib>SHATTUCK, Donna</creatorcontrib><creatorcontrib>STONE, Steven</creatorcontrib><creatorcontrib>HENSEL, Charles H</creatorcontrib><creatorcontrib>GUTIN, Alexander</creatorcontrib><creatorcontrib>NEFF, Chris D</creatorcontrib><creatorcontrib>RUSSELL, Deanna L</creatorcontrib><creatorcontrib>TRAN, Thanh</creatorcontrib><creatorcontrib>XIANKANG HONG</creatorcontrib><creatorcontrib>JAMMULAPATI, Srikanth</creatorcontrib><creatorcontrib>RILEY, Robyn</creatorcontrib><title>Linkage of body mass index to chromosome 20 in Utah pedigrees</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a maximum multipoint heterogeneity LOD score of 3.5 at D20S438 (55.1 cM). Two additional analyses were performed. First, a one-gene, two-mutation model (with one dominant mutation and one recessive mutation) increased the LOD score to 4.2. Second, a two-locus model (with one locus dominant and one recessive) generated a multipoint LOD score of 4.9. We conclude that one or more severe obesity predisposing genes lie within an interval of approx. 10 cM on chromosome 20. This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Centromere - genetics</subject><subject>Chromosomes, Human, Pair 20 - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Dominant</subject><subject>Genes, Recessive</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Molecular and cellular biology</subject><subject>Obesity - genetics</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Utah</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqF0D1PwzAQgGELgWgpjKzIC2yB80fsZGBAFV9SJRY6R45zaQNJXOxUov8eo0aqmJjudHp0w0vIJYNbBqDvAoAUOcQ9zdgRmTIpeMI4iGMyBSEhUZrpCTkL4QOApTlPT8mEMQ2cQzYl94um_zQrpK6mpat2tDMh0Kav8JsOjtq1d50LrkPKIZ7pcjBrusGqWXnEcE5OatMGvBjnjCyfHt_nL8ni7fl1_rBIrEhhSDADrVgKRqARWslSCzDSVGirPLccTMZEyaNVZW2E1FleMxY1QK4qBCtm5Gb_d-Pd1xbDUHRNsNi2pke3DYXmXEmu4F_Icq5jKBFhsofWuxA81sXGN53xu4JB8Ru2-BM2-qvx8bbssDrosWQE1yMwwZq29qa3TTg4GdtL4OIH0sx9BA</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>HUNT, Steven C</creator><creator>ABKEVICH, Victor</creator><creator>WEAVER-FELDHAUS, Jane</creator><creator>MACALMA, Tess</creator><creator>RICHARDS, Maria M</creator><creator>GRESS, Richard</creator><creator>FRANCIS, Mike</creator><creator>THOMAS, Alun</creator><creator>FRECH, Georges C</creator><creator>ADAMS, Ted D</creator><creator>SHATTUCK, Donna</creator><creator>STONE, Steven</creator><creator>HENSEL, Charles H</creator><creator>GUTIN, Alexander</creator><creator>NEFF, Chris D</creator><creator>RUSSELL, Deanna L</creator><creator>TRAN, Thanh</creator><creator>XIANKANG HONG</creator><creator>JAMMULAPATI, Srikanth</creator><creator>RILEY, Robyn</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Linkage of body mass index to chromosome 20 in Utah pedigrees</title><author>HUNT, Steven C ; ABKEVICH, Victor ; WEAVER-FELDHAUS, Jane ; MACALMA, Tess ; RICHARDS, Maria M ; GRESS, Richard ; FRANCIS, Mike ; THOMAS, Alun ; FRECH, Georges C ; ADAMS, Ted D ; SHATTUCK, Donna ; STONE, Steven ; HENSEL, Charles H ; GUTIN, Alexander ; NEFF, Chris D ; RUSSELL, Deanna L ; TRAN, Thanh ; XIANKANG HONG ; JAMMULAPATI, Srikanth ; RILEY, Robyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-e8076150a3ea3764b730a4adecd99c20a813b2c356bfa34789f110a30096de0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Centromere - genetics</topic><topic>Chromosomes, Human, Pair 20 - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Dominant</topic><topic>Genes, Recessive</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>Molecular and cellular biology</topic><topic>Obesity - genetics</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Utah</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUNT, Steven C</creatorcontrib><creatorcontrib>ABKEVICH, Victor</creatorcontrib><creatorcontrib>WEAVER-FELDHAUS, Jane</creatorcontrib><creatorcontrib>MACALMA, Tess</creatorcontrib><creatorcontrib>RICHARDS, Maria M</creatorcontrib><creatorcontrib>GRESS, Richard</creatorcontrib><creatorcontrib>FRANCIS, Mike</creatorcontrib><creatorcontrib>THOMAS, Alun</creatorcontrib><creatorcontrib>FRECH, Georges C</creatorcontrib><creatorcontrib>ADAMS, Ted D</creatorcontrib><creatorcontrib>SHATTUCK, Donna</creatorcontrib><creatorcontrib>STONE, Steven</creatorcontrib><creatorcontrib>HENSEL, Charles H</creatorcontrib><creatorcontrib>GUTIN, Alexander</creatorcontrib><creatorcontrib>NEFF, Chris D</creatorcontrib><creatorcontrib>RUSSELL, Deanna L</creatorcontrib><creatorcontrib>TRAN, Thanh</creatorcontrib><creatorcontrib>XIANKANG HONG</creatorcontrib><creatorcontrib>JAMMULAPATI, Srikanth</creatorcontrib><creatorcontrib>RILEY, Robyn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUNT, Steven C</au><au>ABKEVICH, Victor</au><au>WEAVER-FELDHAUS, Jane</au><au>MACALMA, Tess</au><au>RICHARDS, Maria M</au><au>GRESS, Richard</au><au>FRANCIS, Mike</au><au>THOMAS, Alun</au><au>FRECH, Georges C</au><au>ADAMS, Ted D</au><au>SHATTUCK, Donna</au><au>STONE, Steven</au><au>HENSEL, Charles H</au><au>GUTIN, Alexander</au><au>NEFF, Chris D</au><au>RUSSELL, Deanna L</au><au>TRAN, Thanh</au><au>XIANKANG HONG</au><au>JAMMULAPATI, Srikanth</au><au>RILEY, Robyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage of body mass index to chromosome 20 in Utah pedigrees</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>109</volume><issue>3</issue><spage>279</spage><epage>285</epage><pages>279-285</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a maximum multipoint heterogeneity LOD score of 3.5 at D20S438 (55.1 cM). Two additional analyses were performed. First, a one-gene, two-mutation model (with one dominant mutation and one recessive mutation) increased the LOD score to 4.2. Second, a two-locus model (with one locus dominant and one recessive) generated a multipoint LOD score of 4.9. We conclude that one or more severe obesity predisposing genes lie within an interval of approx. 10 cM on chromosome 20. This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>11702208</pmid><doi>10.1007/s004390100581</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human genetics, 2001-09, Vol.109 (3), p.279-285 |
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| language | eng |
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| source | Springer Nature |
| subjects | Biological and medical sciences Body Mass Index Centromere - genetics Chromosomes, Human, Pair 20 - genetics Female Fundamental and applied biological sciences. Psychology Genes, Dominant Genes, Recessive Genetic Linkage Genetic Markers Genotype Humans Lod Score Male Models, Genetic Molecular and cellular biology Obesity - genetics Pedigree Phenotype Utah |
| title | Linkage of body mass index to chromosome 20 in Utah pedigrees |
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