The Rel/NF-κB family: friend and foe

The members of the Rel/NF-κB family of transcription factors form one of the first lines of defense against infectious diseases and cellular stress. These proteins initiate a highly coordinated response in multiple cell types that effectively counteracts the threat to the health of the organism. Con...

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Bibliographic Details
Published in:Trends in Biochemical Sciences 2000-09, Vol.25 (9), p.434-440
Main Author: Perkins, Neil D
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cancer
Cell Division
Cell Line
Cell Nucleus - metabolism
Humans
I-kappa B Proteins - chemistry
I-kappa B Proteins - genetics
I-kappa B Proteins - physiology
IKK
Inflammation
Inflammation - metabolism
IκB
Models, Biological
Multigene Family
Neoplasms
NF-^KB protein
NF-kappa B - chemistry
NF-kappa B - genetics
NF-kappa B - physiology
Rel protein
Transcription
Transcription, Genetic
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Summary:The members of the Rel/NF-κB family of transcription factors form one of the first lines of defense against infectious diseases and cellular stress. These proteins initiate a highly coordinated response in multiple cell types that effectively counteracts the threat to the health of the organism. Conversely, disruption of the regulatory mechanisms that control the specificity and extent of this response, which results in aberrant activation of NF-κB, can be one of the primary causes of a wide range of human diseases. Thus, targeting NF-κB might lead to the development of new pharmaceutical reagents that could provide novel treatments for many inflammatory diseases and cancer.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(00)01617-0