Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals—correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels

The objective of this study was to assess the frequency of blood-brain barrier (BBB) impairment, as measured by the albumin ratio, in neuro-asymptomatic HIV-1-infected individuals without antiretroviral treatment and the correlation between BBB disruption and intrathecal immune activation and HIV-1...

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Bibliographic Details
Published in:Journal of neurovirology 2001-12, Vol.7 (6), p.542-547
Main Author: M Andersson, L Hagberg, D Fuchs, B Svennerholm, M Gisslén, L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-HIV Agents - therapeutic use
Blood-Brain Barrier
Female
HIV Infections - cerebrospinal fluid
HIV Infections - drug therapy
HIV Infections - physiopathology
HIV-1 - genetics
Human immunodeficiency virus 1
Humans
Male
Middle Aged
neopterin
Neopterin - blood
Neopterin - cerebrospinal fluid
RNA, Viral - blood
RNA, Viral - cerebrospinal fluid
Serum Albumin - cerebrospinal fluid
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Summary:The objective of this study was to assess the frequency of blood-brain barrier (BBB) impairment, as measured by the albumin ratio, in neuro-asymptomatic HIV-1-infected individuals without antiretroviral treatment and the correlation between BBB disruption and intrathecal immune activation and HIV-1 RNA levels. Serum and cerebrospinal fluid (CSF) albumin, neopterin, and HIV-1 RNA levels were analysed in 110 neuro-asymptomatic HIV-1-infected individuals at different stages of disease; 63 classified as CDC A, 25 as CDC B, and 22 as CDC C. Increased BBB permeability was found in 17 of 110 (15%) of HIV-1-infected individuals. This proportion was sustained throughout the CDC stages. The albumin ratio was correlated with the CSF neopterin levels (r s = 0.36, P < 0.001), the serum neopterin levels (r s = 0.37, P < 0.001), and the CSF HIV-1 RNA levels (r s = 0.26, P < 0.01), but not with the plasma HIV-1 RNA levels. The correlations between the albumin ratio and the CSF and serum neopterin concentrations and the CSF HIV-1 RNA levels indicate that immune activation and, possibly, intrathecal HIV-1 virus replication are important factors associated with increased BBB permeability in HIV-1 infection.
ISSN:1355-0284
1538-2443
DOI:10.1080/135502801753248123