Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet

Several investigations have shown heterogeneity in the functional responses to angiotensin II (Ang II) in patients with essential hypertension. The present study was initiated to evaluate whether the A(1166)C polymorphism of the Ang II type 1 receptor (AT(1)R) gene contributes to this variability in...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-09, Vol.36 (3), p.411-416
Main Authors: Spiering, W, Kroon, A A, Fuss-Lejeune, M M, Daemen, M J, de Leeuw, P W
Format: Article
Language:English
Subjects:
Adult
Angiotensin II - blood
Angiotensin II - pharmacology
Blood Pressure - drug effects
Blood Pressure - physiology
Diet
Female
Fluorescent Antibody Technique, Direct
Genotype
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Heart Rate - drug effects
Heart Rate - physiology
Hemodynamics - drug effects
Hemodynamics - physiology
Humans
Male
Middle Aged
Organ Specificity
Polymerase Chain Reaction - methods
Polymorphism, Genetic
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - genetics
Renal Circulation - drug effects
Renal Circulation - physiology
Sodium Chloride, Dietary - administration & dosage
Vascular Resistance - drug effects
Vascular Resistance - physiology
Vasoconstrictor Agents - blood
Vasoconstrictor Agents - pharmacology
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Summary:Several investigations have shown heterogeneity in the functional responses to angiotensin II (Ang II) in patients with essential hypertension. The present study was initiated to evaluate whether the A(1166)C polymorphism of the Ang II type 1 receptor (AT(1)R) gene contributes to this variability in Ang II responses. After 7 days of a high-sodium diet (220 mmol Na(+) per day), we measured in 42 essential hypertensive patients blood pressure, heart rate, effective renal plasma flow (ERPF), glomerular filtration rate (GFR), active plasma renin concentration, aldosterone, and atrial natriuretic peptide (ANP) before and during Ang II infusion (increasing doses of 0.3, 1.0, and 3.0 ng/kg per minute). Calculated variables were filtration fraction and renal vascular resistance (RVR). Patients in the 3 genotype groups (AA: n=14; AC: n=17; CC: n=11) were matched for gender, age, and body mass index. At baseline, CC patients had decreased GFR (P:=0.06) and aldosterone (P:
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.36.3.411