Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus

Increased risk of coronary heart disease in patients with type 2 diabetes cannot be accounted for by differences in conventional risk factors. This study demonstrates that plasma concentrations of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, are increased in patient...

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Bibliographic Details
Published in:The American journal of cardiology 2001-11, Vol.88 (10), p.1201-1203
Main Authors: Abbasi, Fahim, Asagmi, Tomoko, Cooke, John P., Lamendola, Cindy, McLaughlin, Tracey, Reaven, Gerald M., Stuehlinger, Markus, Tsao, Philip S.
Format: Article
Language:English
Subjects:
Arginine - analogs & derivatives
Arginine - blood
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Glucose
Cardiology. Vascular system
Cardiovascular disease
Case-Control Studies
Cholesterol - blood
Diabetes
Diabetes Mellitus, Type 2 - blood
Enzyme Inhibitors - blood
Female
Humans
Male
Medical research
Medical sciences
Middle Aged
Nitric Oxide Synthase - antagonists & inhibitors
Plasma
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Summary:Increased risk of coronary heart disease in patients with type 2 diabetes cannot be accounted for by differences in conventional risk factors. This study demonstrates that plasma concentrations of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, are increased in patients with type 2 diabetes, thereby identifying a new and potentially important coronary heart disease risk factor in this patient population.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(01)02063-X