Possible Involvement of p38 Mitogen-Activated Protein Kinase in Decidual Function in Parturition

We designed the present study to elucidate the molecular mechanism for parturition, focusing on p38 mitogen-activated protein kinase (p38). The kinase activity of p38 in mouse uterus was gestation stage-dependent, and was markedly increased on day 19 of gestation and during labor. Immunohistochemica...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2001-11, Vol.288 (5), p.1155-1161
Main Authors: Takanami-Ohnishi, Yoko, Asada, Sachie, Tsunoda, Hajime, Fukamizu, Akiyoshi, Goto, Katsutoshi, Yoshikawa, Hiroyuki, Kubo, Takeshi, Sudo, Tatsuhiko, Kimura, Sadao, Kasuya, Yoshitoshi
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Cyclooxygenase 2
Decidua - enzymology
Decidua - physiology
decidual cell
Dinoprost - biosynthesis
Female
Humans
Imidazoles - pharmacology
Immunohistochemistry
Isoenzymes - biosynthesis
Kinetics
Labor, Obstetric - physiology
Membrane Proteins
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinases - immunology
Mitogen-Activated Protein Kinases - physiology
p38 MAPK
p38 Mitogen-Activated Protein Kinases
parturition
Pregnancy
Prostaglandin-Endoperoxide Synthases - biosynthesis
Pyridines - pharmacology
Uterus - enzymology
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Summary:We designed the present study to elucidate the molecular mechanism for parturition, focusing on p38 mitogen-activated protein kinase (p38). The kinase activity of p38 in mouse uterus was gestation stage-dependent, and was markedly increased on day 19 of gestation and during labor. Immunohistochemical examination with anti-phospho p38 antibody revealed that activated p38 was predominantly localized in decidual stromal cells stained with anti-prolactin antibody. In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F2α production and COX-2 expression induced by stimulation with IL-1β. These results suggest that the p38 signaling pathway is involved in decidual function at the late stage of gestation and may contribute to parturition.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2001.5895