Siblings of Patients With Severe Chronic Obstructive Pulmonary Disease Have a Significant Risk of Airflow Obstruction

Although familial clustering has been described, few studies have quantified the risk of airflow obstruction in siblings of patients with chronic obstructive pulmonary disease (COPD). One hundred fifty-two subjects with airflow obstruction and a low gas transfer factor (but without PiZ alpha(1)-anti...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2001-10, Vol.164 (8), p.1419-1424
Main Authors: McCLOSKEY, SEAN C, PATEL, BIPEN D, HINCHLIFFE, SUSAN J, REID, ELAINE D, WAREHAM, NICHOLAS J, LOMAS, DAVID A
Format: Article
Language:English
Subjects:
Aged
Airway Obstruction - epidemiology
Airway Obstruction - genetics
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Emphysema - epidemiology
Emphysema - genetics
Female
Humans
Male
Medical sciences
Middle Aged
Pneumology
Prevalence
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Risk Factors
Severity of Illness Index
Smoking - adverse effects
Smoking - epidemiology
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Summary:Although familial clustering has been described, few studies have quantified the risk of airflow obstruction in siblings of patients with chronic obstructive pulmonary disease (COPD). One hundred fifty-two subjects with airflow obstruction and a low gas transfer factor (but without PiZ alpha(1)-antitrypsin deficiency) were identified and 150 were enrolled in the study. Complete data were obtained from 173 of 221 siblings of these subjects. Forty-four of 126 current or ex-smoking siblings had airflow obstruction (FEV(1)/FVC < 0.7) and 36 also had a FEV(1) < 80% predicted, in keeping with COPD. One hundred eleven current or ex-smoking siblings were matched for age, sex, and smoking history with 419 subjects, without a known family history of COPD, from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort. The prevalence of COPD was much lower in the EPIC group (9.3%) when compared with the siblings (31.5%; odds ratio, 4.70; 95% confidence interval, 2.63 to 8.41). The odds ratio for COPD in siblings with less than a 30 pack-year smoking history was 5.39 (95% confidence interval, 2.49 to 11.67) when compared with matched control subjects. Taken together these results demonstrate a significant familial risk of airflow obstruction in smoking siblings of patients with severe COPD.
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.164.8.2105002