Association analysis of IL1A and IL1B variants in alopecia areata

Alopecia areata is an inflammatory hair loss disease with a major genetic component. The disease is characterized by focal inflammatory lesions with perifollicular T-cell infiltrates, reflecting the role of local cytokine production in the development of patchy hair loss. IL-1α and IL-1β are importa...

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Bibliographic Details
Published in:Heredity 2001-08, Vol.87 (2), p.215-219
Main Authors: Tazi-Ahnini, Rachid, McDonagh, Andrew J G, Cox, Angela, Messenger, Andrew G, Britton, James E R, Ward, Simon J, Båvik, Claes O, Duff, Gordon W, Cork, Michael J
Format: Article
Language:English
Subjects:
Adult
alopecia areata
Alopecia Areata - genetics
Alopecia Areata - immunology
Biomedical and Life Sciences
Biomedicine
Cytogenetics
Ecology
Evolutionary Biology
Female
Genetic Markers
Genotypes
Hair
HLA
Human Genetics
Humans
IL1A
IL1B
Interleukin-1 - genetics
Interleukin-1 - immunology
interleukin‐1
Linkage Disequilibrium
Male
Multigene Family
original-article
Plant Genetics and Genomics
polymorphism
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Summary:Alopecia areata is an inflammatory hair loss disease with a major genetic component. The disease is characterized by focal inflammatory lesions with perifollicular T-cell infiltrates, reflecting the role of local cytokine production in the development of patchy hair loss. IL-1α and IL-1β are important inhibitors of hair growth in vitro . Their effect is opposed by the interleukin-1 receptor antagonist, IL-1ra. Genes of the IL-1 cluster are candidate genes in the pathogenesis of alopecia areata. To investigate the role of the IL-1 system in alopecia areata we examined three biallelic polymorphisms within the IL-1 gene cluster ( IL1A +4845, IL1B +3954 and IL1B –511) in 165 patients and a large number of matched controls ( n =1150). There was no significant association of IL1B –511 or IL1B +3954 genotypes with the overall dataset, or with disease severity or age at onset, in contrast with a previous report. The results suggested the possibility of an association with IL1A +4845 in the overall dataset [OR 1.39 (95% CI 1.00, 1.93)] although this was not statistically significant. This was due mainly to the contribution from mild cases of alopecia areata [OR 1.48 (0.96, 2.29)], suggesting that IL-1α may have a particular role in the pathogenesis of this subgroup.
ISSN:0018-067X
1365-2540
DOI:10.1046/j.1365-2540.2001.00916.x