Expression screening for Lhx3 downstream genes identifies Thg-1pit as a novel mouse gene involved in pituitary development

Thg-1pit, a novel mouse gene, was detected in a screen for genes that are differentially expressed in the developing pituitary of wild-type and Lhx3 null mutant embryos. The predicted translation product of the Thg-1pit gene contains a C-terminal TSC-box adjacent to a leucine zipper motif. These fea...

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Bibliographic Details
Published in:Gene 2001-10, Vol.278 (1), p.125-130
Main Authors: Fiorenza, Maria Teresa, Mukhopadhyay, Mahua, Westphal, Heiner
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary - chemistry
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
Embryo, Mammalian - metabolism
Female
Gene Expression Regulation, Developmental
Homeodomain Proteins - genetics
In Situ Hybridization
leucine zipper
Lhx3 gene
LIM-Homeodomain Proteins
Male
Mice
Molecular Sequence Data
Mutation
Pituitary Gland - embryology
Pituitary Gland - metabolism
Proteins - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
THG-1
Thg-1pit gene
Transcription Factors
TSC-22/DIP/bun
TSC-box
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Summary:Thg-1pit, a novel mouse gene, was detected in a screen for genes that are differentially expressed in the developing pituitary of wild-type and Lhx3 null mutant embryos. The predicted translation product of the Thg-1pit gene contains a C-terminal TSC-box adjacent to a leucine zipper motif. These features are characteristic for the TSC-22/DIP/bun family of proteins. The onset of prominent Thg-1pit expression coincides with Lhx3 activation at early stages of pituitary development. Expression is further enhanced as cells begin to differentiate within the developing pituitary gland. No expression is observed in the pituitary rudiment of mutants that lack Lhx3 function. A possible role is thus suggested for Lhx3 activities in the regulation of Thg-1pit function during early steps of pituitary organogenesis.
ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(01)00715-6