The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the clonin...

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Bibliographic Details
Published in:European neuropsychopharmacology 2001-12, Vol.11 (6), p.449-455
Main Authors: Bannon, Michael J, Michelhaugh, Sharon K, Wang, Jun, Sacchetti, Paola
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Dopamine - genetics
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Gene expression
Gene Order - genetics
Gene polymorphisms
Humans
Membrane Glycoproteins
Membrane Transport Proteins - biosynthesis
Membrane Transport Proteins - chemistry
Membrane Transport Proteins - genetics
Mental Disorders - genetics
Mental Disorders - metabolism
Molecular Sequence Data
Nerve Tissue Proteins
Neuron-restrictive silencer
nurr1
Transcription, Genetic - genetics
Transcriptional regulation
Variable number tandem repeat
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Summary:The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation.
ISSN:0924-977X
1873-7862
DOI:10.1016/S0924-977X(01)00122-5