Dimerization of Human Growth Hormone in the Presence of Metal Ions

Zn2+ and Co2+ ions are known to promote human growth hormone reversible dimerization. In these studies, dimerization was also shown to be initiated by nine other metal ions:  Cd2+, Hg2+, Cu2+, Ag+, Au3+, Au+, Pd2+, Ni2+, and Pt4+. In some cases (Hg2+, Ag+, Au3+, and Ni2+) formation of higher oligome...

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Bibliographic Details
Published in:Bioconjugate chemistry 2000-09, Vol.11 (5), p.646-651
Main Authors: Dienys, Gervydas, Sereikaitė, Jolanta, Lukša, Virgis, Jarutienė, Ona, Mištinienė, Edita, Bumelis, Vladas-Algirdas
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Cations
Cross-Linking Reagents
Dimerization
Human Growth Hormone - chemistry
Human Growth Hormone - drug effects
Humans
Metals, Heavy - pharmacology
Molecular Sequence Data
Peptide Fragments - chemistry
Triazines - pharmacology
Trypsin
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Summary:Zn2+ and Co2+ ions are known to promote human growth hormone reversible dimerization. In these studies, dimerization was also shown to be initiated by nine other metal ions:  Cd2+, Hg2+, Cu2+, Ag+, Au3+, Au+, Pd2+, Ni2+, and Pt4+. In some cases (Hg2+, Ag+, Au3+, and Ni2+) formation of higher oligomers also took place. In addition further detailed investigation of dimerization in the presence of Zn2+ ions was carried out.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc990112j