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Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus
Activator protein-1 (AP-1) was examined at multiple levels (mRNA, DNA binding, composition) in hippocampus of young and aged rats that were behaviorally characterized for spatial memory. GFAP mRNA was measured as a gene product known to increase with aging and to be regulated by AP-1. The activity o...
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Published in: | Neurobiology of aging 2001-09, Vol.22 (5), p.773-786 |
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description | Activator protein-1 (AP-1) was examined at multiple levels (mRNA, DNA binding, composition) in hippocampus of young and aged rats that were behaviorally characterized for spatial memory. GFAP mRNA was measured as a gene product known to increase with aging and to be regulated by AP-1. The activity of Jun-amino terminal-kinase (JNK) was also assessed. Levels of c-jun and c-fos mRNAs were unchanged with aging or spatial learning ability. Abundance of GFAP mRNA was significantly increased in aged hippocampus but did not correlate with spatial learning. Total AP-1 binding activity was unaltered with age or cognitive ability. In hippocampus of young, aged unimpaired and aged impaired rats, AP-1 consists mainly of c-Jun, phosphorylated c-Jun (p-c-Jun), JunD, and smaller amounts of c-Fos. JNK is constitutively active in young and aged hippocampus. We conclude that the basal expression of c-fos and c-jun mRNA, overall AP-1 binding activity and AP-1 composition are not influenced by aging or cognitive ability. |
doi_str_mv | 10.1016/s0197-4580(01)00240-8 |
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JNK is constitutively active in young and aged hippocampus. We conclude that the basal expression of c-fos and c-jun mRNA, overall AP-1 binding activity and AP-1 composition are not influenced by aging or cognitive ability.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/s0197-4580(01)00240-8</identifier><identifier>PMID: 11705637</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Science</publisher><subject>Aging - physiology ; Anatomical correlates of behavior ; Animals ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Cognition - physiology ; Fundamental and applied biological sciences. 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R</creatorcontrib><creatorcontrib>HOYT, E. C</creatorcontrib><creatorcontrib>GALLAGHER, M</creatorcontrib><creatorcontrib>SCHWABE, R. F</creatorcontrib><creatorcontrib>LUND, P. K</creatorcontrib><title>Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Activator protein-1 (AP-1) was examined at multiple levels (mRNA, DNA binding, composition) in hippocampus of young and aged rats that were behaviorally characterized for spatial memory. GFAP mRNA was measured as a gene product known to increase with aging and to be regulated by AP-1. The activity of Jun-amino terminal-kinase (JNK) was also assessed. Levels of c-jun and c-fos mRNAs were unchanged with aging or spatial learning ability. Abundance of GFAP mRNA was significantly increased in aged hippocampus but did not correlate with spatial learning. Total AP-1 binding activity was unaltered with age or cognitive ability. In hippocampus of young, aged unimpaired and aged impaired rats, AP-1 consists mainly of c-Jun, phosphorylated c-Jun (p-c-Jun), JunD, and smaller amounts of c-Fos. JNK is constitutively active in young and aged hippocampus. We conclude that the basal expression of c-fos and c-jun mRNA, overall AP-1 binding activity and AP-1 composition are not influenced by aging or cognitive ability.</description><subject>Aging - physiology</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - physiology</subject><subject>Glial Fibrillary Acidic Protein - genetics</subject><subject>Hippocampus - physiology</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Male</subject><subject>MAP Kinase Kinase 4</subject><subject>Maze Learning - physiology</subject><subject>Mitogen-Activated Protein Kinase Kinases - metabolism</subject><subject>Protein Binding - physiology</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Proto-Oncogene Proteins c-jun - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>RNA, Messenger - analysis</subject><subject>Space Perception - physiology</subject><subject>Transcription Factor AP-1 - genetics</subject><subject>Transcription Factor AP-1 - metabolism</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqF0D1PwzAQgGELgaAUfgLICwiGwJ3txM5YofIhVQLxMVvu1S5BaRLiBKn_npZWMDLd8px9ehk7QbhCwOw6AuY6UamBC8BLAKEgMTtsgGlqElS53mWDX3LADmP8AACtdLbPDhA1pJnUA_Y8DsFTx-vA3dxzV8041fOq6Iovz2Pnuj7yuuJTF13JS__lSz56SpA7WomiW_Ki4q3r-HvRNDW5RdPHI7YXXBn98XYO2dvt-PXmPpk83j3cjCYJKaO6hNCAmHqjcXUIaMrJ0UzkShkSqRDGYCA9E8ZNgwSvDWUhqECSgpKpyXM5ZOebd5u2_ux97OyiiOTL0lW-7qPVQmgJSv8L0cjMaL2G6QZSW8fY-mCbtli4dmkR7Lq6fVknteukFtD-VLdmtXe6_aCfLvzsb2ubeQXOtsBFcmVoXUVF_HMKJZhMym_ViokR</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>SMITH, D. 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K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-c1802be87163707c9cacd29448c2522881fc7d28abf30e78c6ff4fc3cf4358993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging - physiology</topic><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - physiology</topic><topic>Glial Fibrillary Acidic Protein - genetics</topic><topic>Hippocampus - physiology</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>Male</topic><topic>MAP Kinase Kinase 4</topic><topic>Maze Learning - physiology</topic><topic>Mitogen-Activated Protein Kinase Kinases - metabolism</topic><topic>Protein Binding - physiology</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Proto-Oncogene Proteins c-jun - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>RNA, Messenger - analysis</topic><topic>Space Perception - physiology</topic><topic>Transcription Factor AP-1 - genetics</topic><topic>Transcription Factor AP-1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SMITH, D. R</creatorcontrib><creatorcontrib>HOYT, E. C</creatorcontrib><creatorcontrib>GALLAGHER, M</creatorcontrib><creatorcontrib>SCHWABE, R. F</creatorcontrib><creatorcontrib>LUND, P. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SMITH, D. R</au><au>HOYT, E. C</au><au>GALLAGHER, M</au><au>SCHWABE, R. F</au><au>LUND, P. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>22</volume><issue>5</issue><spage>773</spage><epage>786</epage><pages>773-786</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Activator protein-1 (AP-1) was examined at multiple levels (mRNA, DNA binding, composition) in hippocampus of young and aged rats that were behaviorally characterized for spatial memory. GFAP mRNA was measured as a gene product known to increase with aging and to be regulated by AP-1. The activity of Jun-amino terminal-kinase (JNK) was also assessed. Levels of c-jun and c-fos mRNAs were unchanged with aging or spatial learning ability. Abundance of GFAP mRNA was significantly increased in aged hippocampus but did not correlate with spatial learning. Total AP-1 binding activity was unaltered with age or cognitive ability. In hippocampus of young, aged unimpaired and aged impaired rats, AP-1 consists mainly of c-Jun, phosphorylated c-Jun (p-c-Jun), JunD, and smaller amounts of c-Fos. JNK is constitutively active in young and aged hippocampus. We conclude that the basal expression of c-fos and c-jun mRNA, overall AP-1 binding activity and AP-1 composition are not influenced by aging or cognitive ability.</abstract><cop>London</cop><pub>Elsevier Science</pub><pmid>11705637</pmid><doi>10.1016/s0197-4580(01)00240-8</doi><tpages>14</tpages></addata></record> |
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subjects | Aging - physiology Anatomical correlates of behavior Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Cognition - physiology Fundamental and applied biological sciences. Psychology Gene Expression - physiology Glial Fibrillary Acidic Protein - genetics Hippocampus - physiology JNK Mitogen-Activated Protein Kinases Male MAP Kinase Kinase 4 Maze Learning - physiology Mitogen-Activated Protein Kinase Kinases - metabolism Protein Binding - physiology Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - genetics Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans RNA, Messenger - analysis Space Perception - physiology Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism |
title | Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus |
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