Human T and B cell epitope mapping of Taenia solium paramyosin

Taenia solium paramyosin is an immunodominant antigen in human and porcine cysticercosis that has shown promise as a vaccine candidate against schistosomiasis and some filariasis. There are few studies to identify the immunologically relevant regions of paramyosin. In this work, we characterize the...

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Bibliographic Details
Published in:Parasite immunology 2001-11, Vol.23 (11), p.575-579
Main Authors: Vázquez‐Talavera, José, Solís, Carlos F., Medina‐Escutia, Edith, López, Zoila Morales, Proaño, Jefferson, Correa, Dolores, Laclette, Juan Pedro
Format: Article
Language:English
Subjects:
Animals
Blotting, Western
cysticercosis
Epitope Mapping
Epitopes, B-Lymphocyte - immunology
Epitopes, T-Lymphocyte - immunology
Helminth Proteins - immunology
Humans
Neurocysticercosis - immunology
paramyosin
Peptide Fragments - immunology
Recombinant Proteins - immunology
Taenia - immunology
Taenia solium
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Summary:Taenia solium paramyosin is an immunodominant antigen in human and porcine cysticercosis that has shown promise as a vaccine candidate against schistosomiasis and some filariasis. There are few studies to identify the immunologically relevant regions of paramyosin. In this work, we characterize the humoral and cellular response of neurocysticercotic patients against T. solium paramyosin. Western blots using different recombinant fragments of T. solium paramyosin, showed that the sera from neurocysticercotic patients were strongly reactive against the carboxyl end region, with poor recognition of the central and amino regions. In contrast, the cellular immune response of patients did not show preferential recognition of any region of paramyosin.
ISSN:0141-9838
1365-3024
DOI:10.1046/j.1365-3024.2001.00416.x