Circulating levels of TNFα and TNF receptor superfamily members in lymphoid neoplasia

• Published in: American journal of hematology 2000-10, Vol.65 (2), p.105-110
• Main Authors: Metkar, Sunil S., Naresh, K.N., Manna, Partha P., Srinivas, V., Advani, S.H., Nadkarni, J.J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; CD27; Child; Child, Preschool; Fas; fas Receptor - blood; Female; Hematologic and hematopoietic diseases; Hodgkin Disease - blood; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma - blood; Lymphoma - classification; Lymphoma - pathology; Lymphoma, Non-Hodgkin - blood; Lymphoma, Non-Hodgkin - pathology; Male; Medical sciences; Middle Aged; Neoplasm Proteins - metabolism; Neoplasm Staging; NHL; Receptors, Tumor Necrosis Factor - blood; Solubility; TNFRI; TNFRII; TNFα; Tumor Necrosis Factor Receptor Superfamily, Member 7 - blood; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/1096-8652(200010)65:2<105::AID-AJH3>3.0.CO;2-R

We have correlated the serum levels of TNFα and soluble TNF receptor superfamily members with clinico‐pathologic parameters in patients of Hodgkin's disease (HD, N = 26) and non‐Hodgkin's lymphoma (NHLs, N = 35). HD patients had significantly higher levels of TNFα, sTNFRI, and sTNFRII in serum while NHL patients had significantly higher levels of sTNFRI, sTNFRII, sCD27, and sFas as compared to controls. In NHL patients the levels of sCD27 correlated directly and significantly with the high‐stage disease, bone marrow involvement, lymph nodal presentation, and serum LDH levels. Similarly in NHL patients, levels of sFas also correlated directly and significantly with the presence of high stage disease. HD patients with B symptoms had significantly higher levels of sTNFRII. Am. J. Hematol. 65:105–110, 2000. © 2000 Wiley‐Liss, Inc.