Molecular mechanisms of anticancer activity of natural dietetic products

The efficiency of dietetic supplements in cancer prevention and treatment is a popular and controversial subject of research. New in vitro and in vivo research results indicate that some dietetic supplements do indeed show anticancer activity. The strongest anticancer action has been demonstrated by...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2000-01, Vol.78 (6), p.333-336
Main Authors: COLIC, M, PAVELIC, K
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants - metabolism
Antioxidants - pharmacology
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell Cycle - drug effects
Cyclin-Dependent Kinases - antagonists & inhibitors
Dietary Supplements
Foods and miscellaneous
Medical sciences
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Models, Biological
Signal Transduction - drug effects
Tumors
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Summary:The efficiency of dietetic supplements in cancer prevention and treatment is a popular and controversial subject of research. New in vitro and in vivo research results indicate that some dietetic supplements do indeed show anticancer activity. The strongest anticancer action has been demonstrated by natural compounds with multifunctional activity. For instance, antioxidants, which also bind to and modulate the activity of protein kinases involved in signal transduction cascades show both cytostatic and cytotoxic activity towards cancer cells. Other activities such as angiogenesis inhibition, nitric oxide synthase inhibition, and pro-oxidants production have also been observed. Catechins and polyphenols from plant extracts such as green tea show the strongest anticancer activity. The initial clinical trials with some flavonoid molecules are already underway.
ISSN:0946-2716
1432-1440
DOI:10.1007/s001090000121