The Genes Encoding the Type II Gonadotropin-Releasing Hormone Receptor and the Ribonucleoprotein RBM8A in Humans Overlap in Two Genomic Loci

We have cloned and characterized two genomic loci encoding the human type II gonadotropin-releasing hormone (GnRH) receptor and RNA-binding motif protein-8 (RBM8A). In both loci the genes overlap and are in antisense orientation to each other. The locus on chromosome 1 encompasses the type II GnRH r...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2001-11, Vol.78 (1-2), p.15-18
Main Authors: Faurholm, Bjarne, Millar, Robert P., Katz, Arieh A.
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Sequence
Base Sequence
Biological and medical sciences
Chromosome 1
chromosome 14
Chromosome Mapping
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 14 - genetics
Cloning, Molecular
DNA - chemistry
DNA - genetics
Exons
Female
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes - genetics
Genes, Overlapping - genetics
Genes. Genome
gonadotropin-releasing hormone receptors (type II)
Humans
Introns
Jurkat Cells
Male
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
pseudogenes
Pseudogenes - genetics
RBM8A gene
Receptors, LHRH - genetics
Ribonucleoproteins - genetics
RNA-Binding Proteins - genetics
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Tumor Cells, Cultured
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Summary:We have cloned and characterized two genomic loci encoding the human type II gonadotropin-releasing hormone (GnRH) receptor and RNA-binding motif protein-8 (RBM8A). In both loci the genes overlap and are in antisense orientation to each other. The locus on chromosome 1 encompasses the type II GnRH receptor gene (GNRHR2), which is composed of three exons. We found transcripts from this gene in a wide range of tissues, but they lacked a methionine initiation codon and had a stop codon in exon 2. In the antisense orientation, this locus contains RBM8A, which consists of six exons and directs the synthesis of an RBM8A protein of 173 or 174 amino acids by alternative splicing. A second locus on chromosome 14 contains pseudogenes of RBM8A and the type II GnRH receptor and probably originated from the chromosome 1 locus by retrotransposition.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.2001.6650