Aldosterone, a New Appreciation of Its Role in Heart Failure

Understanding of the role, triggers, and impact of the renin‐angiotensin‐aldosterone system in cardiovascular disease has significantly broadened. In recent years substantial discoveries have been made regarding the pathophysiology of heart failure, particularly in the area of neurohormonal activati...

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Bibliographic Details
Published in:Pharmacotherapy 2000-09, Vol.20 (9), p.1107-1115
Main Authors: Cha, Amy J., Malecha, Susan E., Judge, Kevin W.
Format: Article
Language:English
Subjects:
Aldosterone - biosynthesis
Aldosterone - blood
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
Cardiotonic agents
Cardiovascular system
Heart
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Medical sciences
Mineralocorticoid Receptor Antagonists - therapeutic use
Pharmacology. Drug treatments
Renin-Angiotensin System - physiology
Spironolactone - therapeutic use
Survival Analysis
Vasoconstriction - physiology
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Summary:Understanding of the role, triggers, and impact of the renin‐angiotensin‐aldosterone system in cardiovascular disease has significantly broadened. In recent years substantial discoveries have been made regarding the pathophysiology of heart failure, particularly in the area of neurohormonal activation. New interest in therapy with aldosterone antagonists was stimulated by results of a 2‐year study of 1663 patients with heart failure that showed a 30% relative risk reduction of death among patients given a subhemodynamic dosage of spironolactone, a nonselective aldosterone antagonist, compared with placebo, in addition to standard therapy of diuretics, angiotensin‐converting enzyme inhibitors, β‐blockers, and digitalis.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.20.13.1107.35023