The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer

Objective: The aim of this study was to analyse the vascular endothelial growth factor (VEGF) expression in a series of cervical carcinomas and to compare the results with the microvessel density (MVD) and clinicopathological features. Study design: The immunoreactivity for VEGF was studied in 130 i...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2000-10, Vol.92 (2), p.251-257
Main Authors: Tjalma, Wiebren, Weyler, Joost, Weyn, Barbara, Van Marck, Eric, Van Daele, André, Van Dam, Peter, Goovaerts, Gerda, Buytaert, Philippe
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adult
Aged
Angiogenesis
Biological and medical sciences
Carcinoma, Adenosquamous - blood supply
Carcinoma, Adenosquamous - chemistry
Carcinoma, Adenosquamous - pathology
Carcinoma, Squamous Cell - blood supply
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - pathology
CD 31
Endothelial Growth Factors - analysis
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Invasive cervical cancer
Lymphokines - analysis
Medical sciences
Microcirculation - pathology
Middle Aged
Prognosis
Tumors
Uterine Cervical Neoplasms - blood supply
Uterine Cervical Neoplasms - chemistry
Uterine Cervical Neoplasms - pathology
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
VEGF
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Summary:Objective: The aim of this study was to analyse the vascular endothelial growth factor (VEGF) expression in a series of cervical carcinomas and to compare the results with the microvessel density (MVD) and clinicopathological features. Study design: The immunoreactivity for VEGF was studied in 130 invasive cervical carcinomas and in 22 patients with a carcinoma in situ of the cervix. The results were compared with the MVD. Results: Staining for VEGF of less then 50% per slide occurred in 80% of the invasive carcinomas and in 82% of the in situ carcinomas. The median MVD was 261 vv/mm 2 (range: 11–1000) in the invasive group and 146 vv/mm 2 (range: 25–536) in the in situ group. Unlike the microvessel density there was no association between VEGF expression and survival. The MVD was higher in VEGF poorer (
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(99)00295-X