The molecular revolution in the development of vaccines against ectoparasites

Over the last decade, the application of a spectrum of molecular techniques has begun to revolutionise our understanding of protective immune responses to ectoparasites and the targets for those responses. The catalogue of potential and actual protective antigens characterised in detail is slowly ex...

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Bibliographic Details
Published in:Veterinary parasitology 2001-11, Vol.101 (3), p.353-368
Main Author: Willadsen, Peter
Format: Article
Language:English
Subjects:
Animals
Antigen
DNA, Recombinant
Ectoparasite
Ectoparasitic Infestations - immunology
Ectoparasitic Infestations - prevention & control
Ectoparasitic Infestations - veterinary
Immunisation
Insecta - immunology
Myiasis
Tick
Tick Infestations - immunology
Tick Infestations - prevention & control
Tick Infestations - veterinary
Ticks - immunology
Vaccination - veterinary
Vaccine
Vaccines - genetics
Vaccines - immunology
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Summary:Over the last decade, the application of a spectrum of molecular techniques has begun to revolutionise our understanding of protective immune responses to ectoparasites and the targets for those responses. The catalogue of potential and actual protective antigens characterised in detail is slowly expanding. The validity of regarding such antigens as generic and capable of cross-species protection is being explored. The immune interactions between host and parasite are being studied at a molecular rather than cellular level. All this should contribute to the eventual development of a range of recombinant vaccines, though important scientific limitations remain. These range from the innate susceptibility of individual parasite species to immunological attack, which can only be assessed on a case by case basis, to our ability to produce the desired recombinant antigens and to elicit and maintain the necessary immunological responses.
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(01)00560-X