Rho family GTPases: more than simple switches

Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emph...

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Published in:Trends in Cell Biology 2000-10, Vol.10 (10), p.415-419
Main Authors: Symons, Marc, Settleman, Jeff
Format: Article
Language:English
Subjects:
Cell signalling
Cytoskeleton
GAP
GDI
GEF
GTPase
Guanosine Diphosphate - metabolism
Guanosine Triphosphate - metabolism
Plasma membrane
Rho
rho GTP-Binding Proteins - metabolism
Signal Transduction - physiology
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description Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.
doi_str_mv 10.1016/S0962-8924(00)01832-8
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subjects Cell signalling
Cytoskeleton
GAP
GDI
GEF
GTPase
Guanosine Diphosphate - metabolism
Guanosine Triphosphate - metabolism
Plasma membrane
Rho
rho GTP-Binding Proteins - metabolism
Signal Transduction - physiology
title Rho family GTPases: more than simple switches
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