Body composition in Prader-Willi syndrome compared with nonsyndromal obesity: Relationship to physical activity and growth hormone function

Objective: To study the relationship of fat mass, extracellular-to-intracellular-water ratio, and bone mineral density with growth hormone function and physical activity in Prader-Willi syndrome. Study design: There were 17 patients with PWS (10 women, ages 7.5-19.8 years) and 17 obese control patie...

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Bibliographic Details
Published in:The Journal of pediatrics 2001-11, Vol.139 (5), p.708-714
Main Authors: van Mil, Edgar G.A.H., Westerterp, Klaas R., Gerver, Willem-Jan M., Van Marken Lichtenbelt, Wouter D., Kester, Arnold D.M., Saris, Wim H.M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Body Composition
Body Water - metabolism
Bone Density
Child
Deuterium Oxide
Exercise - physiology
Extracellular Space - metabolism
Humans
Indicator Dilution Techniques
Intracellular Membranes - metabolism
Medical sciences
Metabolic diseases
Obesity
Obesity - physiopathology
Prader-Willi Syndrome - physiopathology
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Summary:Objective: To study the relationship of fat mass, extracellular-to-intracellular-water ratio, and bone mineral density with growth hormone function and physical activity in Prader-Willi syndrome. Study design: There were 17 patients with PWS (10 women, ages 7.5-19.8 years) and 17 obese control patients, matched for gender and bone age. FM and extracellular-to-intracellular-water ratio were measured by bromide-deuterium dilution, BMD by dual-energy x-ray absorptiometry, GH function by fasted serum insulin-like growth factor-I concentration, and physical activity by doubly-labeled water in combination with basal metabolic rate by a ventilated hood. Results: The PWS group had a similar fat mass, but a lower fat-free mass, whereas the extracellular-to-intracellular-water ratio was higher compared with the control group (0.87 ± 0.07 l/l and 0.80 ± 0.06 l/l, respectively [P
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2001.118399