Immunodiagnosis of schistosomiasis by determination of the circulating antigens CAA and CCA, in particular in individuals with recent or light infections

In the present paper, we evaluate determination of circulating anodic (CAA) and cathodic (CCA) antigen for the diagnosis of an active Schistosoma infection in humans, in comparison to the diagnostic performance of parasitological examination and the demonstration of specific antibodies. Illustrated...

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Bibliographic Details
Published in:Acta tropica 2000-10, Vol.77 (1), p.69-80
Main Authors: van Lieshout, L, Polderman, A.M, Deelder, A.M
Format: Article
Language:English
Subjects:
Animals
Antigens, Helminth - blood
Antigens, Helminth - urine
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
CAA
CCA
Circulating antigen
Diagnosis
Diseases caused by trematodes
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Glycoproteins - blood
Glycoproteins - urine
Helminth Proteins - blood
Helminth Proteins - urine
Helminthic diseases
Humans
Infectious diseases
Medical sciences
Parasitic diseases
Schistosoma - immunology
Schistosomiases
Schistosomiasis
Schistosomiasis - immunology
Schistosomiasis - parasitology
Sensitivity and Specificity
Serologic Tests
Tropical medicine
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Summary:In the present paper, we evaluate determination of circulating anodic (CAA) and cathodic (CCA) antigen for the diagnosis of an active Schistosoma infection in humans, in comparison to the diagnostic performance of parasitological examination and the demonstration of specific antibodies. Illustrated by three different studies, which all deal with the diagnosis of either recent or low intensity infections, we further discuss our experiences with these diagnostic methods. For the diagnosis of recent infections, specific antibody determination showed to be very sensitive, particularly in individuals originating from non-endemic areas. For the assessment of cure and for the diagnosis of active infections in endemic areas, the methods of choice are parasitological examination and CAA or CCA determination. Depending on infection levels of the target population and on logistic conditions, CAA and CCA determination may either replace parasitological examination or, in the case of light infections, may be used as a complementary diagnostic tool.
ISSN:0001-706X
1873-6254
DOI:10.1016/S0001-706X(00)00115-7