Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration

Neural stem cells have recently come to the forefront in neurobiology because of the possibilities for CNS repair by transplantation. Further understanding of the biology of these cells is critical for making their use in CNS repair possible. It is likely that these discoveries will also have spin-o...

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Bibliographic Details
Published in:Journal of neuro-oncology 2001-06, Vol.53 (2), p.203-212
Main Author: Dirks, P B
Format: Article
Language:English
Subjects:
Animals
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain Tissue Transplantation
Cell Differentiation
Cell Division
Cell Lineage
Cell Movement - physiology
Central Nervous System - cytology
Central Nervous System - embryology
Drosophila Proteins
Embryonic and Fetal Development
Fetal Proteins - physiology
Fetal Tissue Transplantation
Glioma - metabolism
Glioma - pathology
Glycoproteins - physiology
Humans
Laminin - physiology
Mice
Models, Biological
Morphogenesis
Neoplasm Invasiveness - physiopathology
Neoplasm Proteins - physiology
Nerve Tissue Proteins - physiology
Primates
Rats
Stem Cell Transplantation
Stem Cells - physiology
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Summary:Neural stem cells have recently come to the forefront in neurobiology because of the possibilities for CNS repair by transplantation. Further understanding of the biology of these cells is critical for making their use in CNS repair possible. It is likely that these discoveries will also have spin-offs for neuro-oncology as primary brain tumors may arise from a CNS progenitor cell. An understanding of the normal migratory ability of these cells is also likely to have a very important impact on the knowledge of brain tumor invasion.
ISSN:0167-594X
1573-7373
DOI:10.1023/A:1012273922478