Generation of New Enzymes via Covalent Modification of Existing Proteins

Chemical modification of proteins remains a valuable tool for protein engineering. Qi et al review a variety of approaches in which chemical modification has been used to alter the catalytic properties of existing enzymes to give new catalytic activities to existing enzymes or to impart catalytic ac...

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Bibliographic Details
Published in:Chemical reviews 2001-10, Vol.101 (10), p.3081-3112
Main Authors: Qi, Dongfeng, Tann, Cheng-Min, Haring, Dietmar, Distefano, Mark D
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antibodies, Catalytic - metabolism
Base Sequence
Catalysis
Chemistry
Coenzymes - metabolism
DNA - metabolism
Enzyme Activation
Enzymes
Enzymes - chemistry
Flavoproteins - metabolism
Kinetics
Metalloproteins - chemistry
Metalloproteins - metabolism
Molecular Sequence Data
Molecular Structure
NAD - metabolism
Protein Conformation
Protein Engineering - methods
Proteins
Proteins - chemistry
Selenium - metabolism
Substrate Specificity
Transaminases - metabolism
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Summary:Chemical modification of proteins remains a valuable tool for protein engineering. Qi et al review a variety of approaches in which chemical modification has been used to alter the catalytic properties of existing enzymes to give new catalytic activities to existing enzymes or to impart catalytic activities to proteins normally devoid of enzymatic activity.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr000059o