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Generation of New Enzymes via Covalent Modification of Existing Proteins
Chemical modification of proteins remains a valuable tool for protein engineering. Qi et al review a variety of approaches in which chemical modification has been used to alter the catalytic properties of existing enzymes to give new catalytic activities to existing enzymes or to impart catalytic ac...
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| Published in: | Chemical reviews 2001-10, Vol.101 (10), p.3081-3112 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a442t-d450d6727e93577dbcd4ed56b9e0b92589d6940dc6f1a3a700f81c047729b7fb3 |
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| cites | cdi_FETCH-LOGICAL-a442t-d450d6727e93577dbcd4ed56b9e0b92589d6940dc6f1a3a700f81c047729b7fb3 |
| container_end_page | 3112 |
| container_issue | 10 |
| container_start_page | 3081 |
| container_title | Chemical reviews |
| container_volume | 101 |
| creator | Qi, Dongfeng Tann, Cheng-Min Haring, Dietmar Distefano, Mark D |
| description | Chemical modification of proteins remains a valuable tool for protein engineering. Qi et al review a variety of approaches in which chemical modification has been used to alter the catalytic properties of existing enzymes to give new catalytic activities to existing enzymes or to impart catalytic activities to proteins normally devoid of enzymatic activity. |
| doi_str_mv | 10.1021/cr000059o |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-2665 |
| ispartof | Chemical reviews, 2001-10, Vol.101 (10), p.3081-3112 |
| issn | 0009-2665 1520-6890 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72287257 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Amino Acid Sequence Antibodies, Catalytic - metabolism Base Sequence Catalysis Chemistry Coenzymes - metabolism DNA - metabolism Enzyme Activation Enzymes Enzymes - chemistry Flavoproteins - metabolism Kinetics Metalloproteins - chemistry Metalloproteins - metabolism Molecular Sequence Data Molecular Structure NAD - metabolism Protein Conformation Protein Engineering - methods Proteins Proteins - chemistry Selenium - metabolism Substrate Specificity Transaminases - metabolism |
| title | Generation of New Enzymes via Covalent Modification of Existing Proteins |
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