Genetic and Epigenetic Regulation Schemes: Need for an Alternative Paradigm

Self-organization of living cells results from the tangle of positive and negative feedback developed to ensure their homeostasis and/or their differentiation. There are three major means cellular regulation operates: the genetic, the epigenetic, and the metabolic ones. The regulation type in each o...

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Bibliographic Details
Published in:Molecular Genetics and Metabolism 2000-09, Vol.71 (1-2), p.1-9
Main Author: Roux-Rouquie, Magali
Format: Article
Language:English
Subjects:
Animals
complexity
Drosophila - genetics
Drosophila - growth & development
Drosophila - metabolism
epigenetic
Feedback
Female
Gene Expression Regulation
genetic
Male
Metabolism
Models, Genetic
paradigm
regulation
self-organization
systemics
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Summary:Self-organization of living cells results from the tangle of positive and negative feedback developed to ensure their homeostasis and/or their differentiation. There are three major means cellular regulation operates: the genetic, the epigenetic, and the metabolic ones. The regulation type in each of them has been overviewed. Further examination of relations between complexity and developmental stability points out sui generis properties of feedback loops, which are redundancy and pleiotropy. Prototypical schemes for positive and negative regulation with redundant and pleiotropic (including multifunctional) proteins are presented. They stress a theoretical shift from the analytical to the systemic framework. The systemic paradigm appears to be of increasing interest and importance in the study of concepts for the representation of genetic and epigenetic regulations.
ISSN:1096-7192
1096-7206
DOI:10.1006/mgme.2000.3048