Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs

Potentially lymphotropic 7α- and 7β-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles. The synthes...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-12, Vol.11 (23), p.3011-3014
Main Authors: Fouace, S, El kihel, L, Dherbomez, M, Letourneux, Y
Format: Article
Language:English
Subjects:
Amphotericin B - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biochemistry - methods
Biological and medical sciences
Candida - drug effects
Cholestanols - chemical synthesis
Cholestanols - pharmacology
Drug Evaluation, Preclinical
Flucytosine - pharmacology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Stereoisomerism
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Summary:Potentially lymphotropic 7α- and 7β-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles. The synthesis and biological activity of these fungicidal drugs on resistant strains.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00609-6