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Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs
Potentially lymphotropic 7α- and 7β-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles. The synthes...
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| Published in: | Bioorganic & medicinal chemistry letters 2001-12, Vol.11 (23), p.3011-3014 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c391t-9f68721f26e8b77ccb9bc5920b69b8f07024793bb6cd0e8ec49a43dc9eb5fb743 |
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| cites | cdi_FETCH-LOGICAL-c391t-9f68721f26e8b77ccb9bc5920b69b8f07024793bb6cd0e8ec49a43dc9eb5fb743 |
| container_end_page | 3014 |
| container_issue | 23 |
| container_start_page | 3011 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 11 |
| creator | Fouace, S El kihel, L Dherbomez, M Letourneux, Y |
| description | Potentially lymphotropic 7α- and 7β-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against
Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.
The synthesis and biological activity of these fungicidal drugs on resistant strains. |
| doi_str_mv | 10.1016/S0960-894X(01)00609-6 |
| format | article |
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Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.
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Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.
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Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.
The synthesis and biological activity of these fungicidal drugs on resistant strains.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11714599</pmid><doi>10.1016/S0960-894X(01)00609-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (23), p.3011-3014 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72287488 |
| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Amphotericin B - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biochemistry - methods Biological and medical sciences Candida - drug effects Cholestanols - chemical synthesis Cholestanols - pharmacology Drug Evaluation, Preclinical Flucytosine - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Stereoisomerism |
| title | Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs |
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