Cell death in early neural development: beyond the neurotrophic theory

The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted recognition of the cell death that occurs at earlier stages of neural development, affecting proliferating neural precursor cells and young neuroblas...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2000-10, Vol.23 (10), p.454-458
Main Authors: de la Rosa, Enrique J, de Pablo, Flora
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
Apoptotic Protease-Activating Factor 1
Biological and medical sciences
Caspase 3
Caspase 9
Caspases - deficiency
Caspases - genetics
Caspases - physiology
Cell Division
Cellular biology
Central Nervous System - cytology
Central Nervous System - embryology
Chick Embryo
Embryonic and Fetal Development
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Growth Substances - physiology
Humans
Mice
Mice, Knockout
Morphogenesis
Nerve Growth Factors - physiology
Nervous System - cytology
Nervous System - embryology
Neural crest
Neuroblast
Neuroepithelium
Neurogenesis
Neurology
Neurons - cytology
Neurulation
Proteins - genetics
Proteins - physiology
Retina - cytology
Retina - embryology
Retinal Ganglion Cells - cytology
Vertebrates: nervous system and sense organs
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Summary:The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted recognition of the cell death that occurs at earlier stages of neural development, affecting proliferating neural precursor cells and young neuroblasts. In this article, we briefly present observations supporting the occurrence of programmed cell death during early neural development in a regulated fashion that to some extent parallels the death of projecting neurons lacking neurotrophic support. These findings raise new questions, in particular the magnitude and the role of this early neural cell death.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(00)01628-3