Inflammatory mediators in patients receiving long-term home parenteral nutrition

This study was designed to examine circulating and urine cytokine levels in patients receiving long-term home total parenteral nutrition (TPN) support. Twelve patients who had been receiving home TPN for more than 1 year (range, 1.3-19.5 years) were enrolled for study. To avoid the potential confoun...

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Bibliographic Details
Published in:Digestive diseases and sciences 2001-11, Vol.46 (11), p.2484-2489
Main Authors: LING, Pei-Ra, KHAODHIAR, Lalita, BISTRIAN, Bruce R, KEANE-ELLISON, Mary, THIBAULT, Ann, TAWA, Nicholas
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Case-Control Studies
Enteritis - therapy
Female
Humans
Inflammation Mediators - metabolism
Interleukin-6 - metabolism
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Metabolic diseases
Middle Aged
Parenteral Nutrition, Home Total
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Receptors, Tumor Necrosis Factor - metabolism
Short Bowel Syndrome - therapy
Time Factors
Tumor Necrosis Factor-alpha - metabolism
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Summary:This study was designed to examine circulating and urine cytokine levels in patients receiving long-term home total parenteral nutrition (TPN) support. Twelve patients who had been receiving home TPN for more than 1 year (range, 1.3-19.5 years) were enrolled for study. To avoid the potential confounding effects of intercurrent infection, patients were studied during periods of clinical stability without clinical evidence of infection. Ten normal healthy volunteers served as controls. Serum levels of albumin and C-reactive protein, temperature, body weight, and blood white cell counts were determined. The levels of soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin 6 (IL-6) were measured in serum and 24-hr urine. The results showed that the concentrations of sTNF-RII and IL-6 in 24-hr urine and serum were significantly higher in patients, indicating that long-term home TPN may be associated with a persistent low-grade inflammatory state.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1012388206553