Plasma insulin-like growth factor-1 elevated in mild-to-moderate but not severe heart failure

Insulin-like growth factor 1 (IGF-1) promotes favorable cardiac remodeling in heart failure. However, the relation of plasma IGF-1 in patients with various degrees of heart failure is not known. Venous plasma samples were collected from patients with clinically documented heart failure (n = 24) and...

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Bibliographic Details
Published in:The American heart journal 2001-12, Vol.142 (6), p.E10-E10
Main Authors: Al-Obaidi, M K, Hon, J K, Stubbs, P J, Barnes, J, Amersey, R A, Dahdal, M, Laycock, J F, Noble, M I, Alaghband-Zadeh, J
Format: Article
Language:English
Subjects:
Aged
Female
Heart Failure - blood
Heart Failure - classification
Humans
Insulin-Like Growth Factor I - analysis
Linear Models
Male
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Summary:Insulin-like growth factor 1 (IGF-1) promotes favorable cardiac remodeling in heart failure. However, the relation of plasma IGF-1 in patients with various degrees of heart failure is not known. Venous plasma samples were collected from patients with clinically documented heart failure (n = 24) and from control subjects (n = 21) for measurements of IGF-1 levels. In the heart failure group, functional assessment of the physical capacity was determined by means of the New York Heart Association (NYHA) score. Objective determination of ventricular performance was made by transthoracic echocardiographic measurement of left ventricular fractional shortening (FS). IGF-1 levels were higher in patients with heart failure (mean age, 67 +/- 2 years; 17 men) than in control subjects (age, 71 +/- 2 years; 9 men) (20.2 +/- 2 mU/L, 14.1 +/- 2 mU/L, respectively, P
ISSN:1097-6744