Live or let die – retinal ganglion cell death and survival during development and in the lesioned adult CNS

Programmed cell death or apoptosis is a common and widespread phenomenon that is important for proper development of the nervous system. In the adult CNS, however, apoptosis contributes to secondary cell loss after various types of lesions. The retino-tectal system has been successfully used as a co...

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Bibliographic Details
Published in:Trends in Neurosciences 2000-10, Vol.23 (10), p.483-490
Main Author: Bahr, Mathias
Format: Article
Language:English
Subjects:
Adult
Animals
Apoptosis
Apoptosis - physiology
Apoptotic Protease-Activating Factor 1
BCL-2 family
bcl-2-Associated X Protein
bcl-Associated Death Protein
bcl-X Protein
Biological and medical sciences
Brain Injuries - pathology
Brain-Derived Neurotrophic Factor - pharmacology
Brain-Derived Neurotrophic Factor - physiology
Caenorhabditis elegans - cytology
Caenorhabditis elegans - embryology
Caenorhabditis elegans - growth & development
Carrier Proteins - genetics
Carrier Proteins - physiology
Caspases
Caspases - deficiency
Caspases - genetics
Caspases - physiology
Cell Survival
Cellular biology
Chick Embryo
Eyes & eyesight
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genes, bcl-2
Helminth Proteins - physiology
Humans
Mice
Mice, Knockout
Mitochondria - physiology
Morphogenesis
Nerve Tissue Proteins - deficiency
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neurons
Neuroprotection
Neurotrophins
Proteins - genetics
Proteins - physiology
Proto-Oncogene Proteins - deficiency
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - physiology
Proto-Oncogene Proteins c-bcl-2 - deficiency
Proto-Oncogene Proteins c-bcl-2 - genetics
Proto-Oncogene Proteins c-bcl-2 - physiology
Retina - cytology
Retina - embryology
Retina - growth & development
Retinal ganglion cells
Retinal Ganglion Cells - cytology
Retinal Ganglion Cells - metabolism
Retinal Ganglion Cells - pathology
Vertebrates: nervous system and sense organs
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Summary:Programmed cell death or apoptosis is a common and widespread phenomenon that is important for proper development of the nervous system. In the adult CNS, however, apoptosis contributes to secondary cell loss after various types of lesions. The retino-tectal system has been successfully used as a convenient model system to study the molecular mechanisms of neuronal apoptosis and survival during development and in the lesioned adult CNS. This review describes the current knowledge about the interactions of cell death and survival pathways in general and for retinal ganglion cells specifically.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(00)01637-4