Single nucleotide polymorphisms as tools in human genetics

The development of detailed single nucleotide polymorphism (SNP) maps of the human genome coupled with high-throughput genotyping technologies may allow us to unravel complex genetic traits, such as multifactorial disease or drug response, over the next few years. Here we describe the current effort...

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Bibliographic Details
Published in:Human molecular genetics 2000-10, Vol.9 (16), p.2403-2408
Main Authors: Gray, I C, Campbell, D A, Spurr, N K
Format: Article
Language:English
Subjects:
Genetics, Medical
Genome, Human
Genotype
Humans
Polymorphism, Single Nucleotide
single nucleotide polymorphisms
Online Access:Get full text
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Summary:The development of detailed single nucleotide polymorphism (SNP) maps of the human genome coupled with high-throughput genotyping technologies may allow us to unravel complex genetic traits, such as multifactorial disease or drug response, over the next few years. Here we describe the current efforts to identify and characterize the large numbers of SNPs required and discuss the practicalities of association studies for the identification of genes involved in complex traits.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/9.16.2403